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MAP9 microtubule associated protein 9 [ Homo sapiens (human) ]

Gene ID: 79884, updated on 3-Apr-2024

Summary

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Official Symbol
MAP9provided by HGNC
Official Full Name
microtubule associated protein 9provided by HGNC
Primary source
HGNC:HGNC:26118
See related
Ensembl:ENSG00000164114 MIM:610070; AllianceGenome:HGNC:26118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASAP
Summary
ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in brain (RPKM 7.7), thyroid (RPKM 7.3) and 23 other tissues See more
Orthologs
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Genomic context

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See MAP9 in Genome Data Viewer
Location:
4q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (155342658..155376965, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (158674560..158709763, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156263810..156298117, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y2 Neighboring gene NPY2R antisense RNA 1 Neighboring gene uncharacterized LOC105377502 Neighboring gene MAP9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22081 Neighboring gene TBC1 domain family member 3C pseudogene Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma. Xiao H, et al. Virus Res, 2021 Feb. PMID 33309912
  2. MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population. Liu W, et al. Acta Virol, 2018. PMID 30472874
  3. MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma. Mok EHK, et al. EBioMedicine, 2020 Apr. PMID 32268270, Free PMC Article
  4. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3. Zhang J, et al. EBioMedicine, 2020 Mar. PMID 32151798, Free PMC Article
  5. MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K/AKT signaling pathway. Kong Y, et al. Exp Mol Pathol, 2019 Oct. PMID 31301305

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement.
    Title: MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement.
  2. Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
    Title: Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma.
  3. MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.
    Title: MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma.
  4. MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
    Title: MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.
  5. Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.
    Title: Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3.
  6. Data suggest miR-320a/microtubule-associated protein 9 (MAP9) as promising targets for the treatment and prevention of postmenopausal osteoporosis (PMO).
    Title: MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K/AKT signaling pathway.
  7. MAP9 rs1058992 polymorphism is associated with risk of EBV-associated gastric carcinoma
    Title: MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population.
  8. MAP9 downregulation is associated with colorectal malignancy.
    Title: Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers.
  9. ASAP stabilizes p53 both by alleviating MDM2-mediated p53 ubiquitination and by enhancing its p300-dependent acetylation.
    Title: Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage.
  10. Results highlight dual ASAP regulation by Plk1 and further confirm the importance of ASAP for spindle pole organization, bipolar spindle assembly, and mitosis.
    Title: Plk1 regulates both ASAP localization and its role in spindle pole integrity.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle midzone IEA
Inferred from Electronic Annotation
more info
  
located_in spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
microtubule-associated protein 9
Names
aster-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039580.2 → NP_001034669.1  microtubule-associated protein 9

    See identical proteins and their annotated locations for NP_001034669.1

    Status: VALIDATED

    Source sequence(s)
    AC097467, AY690636, BC022852, CF144347
    Consensus CDS
    CCDS35493.1
    UniProtKB/Swiss-Prot
    Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
    UniProtKB/TrEMBL
    B9EJB6
    Related
    ENSP00000310593.4, ENST00000311277.9
    Conserved Domains (1) summary
    cl01868
    Location:521 → 597
    YukC; WXG100 protein secretion system (Wss), protein YukC

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    155342658..155376965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532255.4 → XP_011530557.1  microtubule-associated protein 9 isoform X3

    UniProtKB/TrEMBL
    B9EJB6
    Conserved Domains (1) summary
    cl01868
    Location:449 → 525
    YukC; WXG100 protein secretion system (Wss), protein YukC

  2. XM_011532254.2 → XP_011530556.1  microtubule-associated protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011530556.1

    UniProtKB/Swiss-Prot
    Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
    UniProtKB/TrEMBL
    B9EJB6
    Conserved Domains (1) summary
    cl01868
    Location:521 → 597
    YukC; WXG100 protein secretion system (Wss), protein YukC

  3. XM_017008616.2 → XP_016864105.1  microtubule-associated protein 9 isoform X2

    UniProtKB/TrEMBL
    B9EJB6
    Conserved Domains (2) summary
    PTZ00121
    Location:280 → 620
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:506 → 591
    PRK12704; phosphodiesterase; Provisional

  4. XM_011532253.2 → XP_011530555.1  microtubule-associated protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011530555.1

    UniProtKB/Swiss-Prot
    Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6
    UniProtKB/TrEMBL
    B9EJB6
    Conserved Domains (1) summary
    cl01868
    Location:521 → 597
    YukC; WXG100 protein secretion system (Wss), protein YukC

  5. XM_017008617.2 → XP_016864106.1  microtubule-associated protein 9 isoform X2

    UniProtKB/TrEMBL
    B9EJB6
    Conserved Domains (2) summary
    PTZ00121
    Location:280 → 620
    PTZ00121; MAEBL; Provisional
    PRK12704
    Location:506 → 591
    PRK12704; phosphodiesterase; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    158674560..158709763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350850.1 → XP_054206825.1  microtubule-associated protein 9 isoform X3

  2. XM_054350847.1 → XP_054206822.1  microtubule-associated protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6

  3. XM_054350848.1 → XP_054206823.1  microtubule-associated protein 9 isoform X2

  4. XM_054350846.1 → XP_054206821.1  microtubule-associated protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6

  5. XM_054350849.1 → XP_054206824.1  microtubule-associated protein 9 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024826.1: Suppressed sequence

    Description
    NM_024826.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q49MG5.3 GenPept UniProtKB/Swiss-Prot:Q49MG5

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