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ZNF669 zinc finger protein 669 [ Homo sapiens (human) ]

Gene ID: 79862, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF669provided by HGNC
Official Full Name
zinc finger protein 669provided by HGNC
Primary source
HGNC:HGNC:25736
See related
Ensembl:ENSG00000188295 AllianceGenome:HGNC:25736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 3.0), testis (RPKM 2.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
1q44
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247099962..247104356, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (246531595..246535990, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247263264..247267658, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZNF670-ZNF695 readthrough (NMD candidate) Neighboring gene zinc finger protein 519 pseudogene Neighboring gene DNA primase subunit 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247208766-247208933 Neighboring gene zinc finger protein 670 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:247241976-247242289 Neighboring gene Sharpr-MPRA regulatory region 11854 Neighboring gene uncharacterized LOC400812 Neighboring gene long intergenic non-protein coding RNA 2897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  2. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 669

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142572.2 → NP_001136044.1  zinc finger protein 669 isoform 2

    See identical proteins and their annotated locations for NP_001136044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) that lacks a segment of the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK056020, CA447495
    Consensus CDS
    CCDS44345.1
    UniProtKB/Swiss-Prot
    Q96BR6
    Related
    ENSP00000404370.2, ENST00000448299.7
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:92 → 350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:278 → 298
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:178 → 202
    zf-H2C2_2; Zinc-finger double domain

  2. NM_024804.3 → NP_079080.2  zinc finger protein 669 isoform 1

    See identical proteins and their annotated locations for NP_079080.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL627095, BC015312, CA447495
    Consensus CDS
    CCDS31088.1
    UniProtKB/Swiss-Prot
    B3KP94, Q5VT39, Q96BR6, Q9H9Q6
    Related
    ENSP00000342818.6, ENST00000343381.10
    Conserved Domains (5) summary
    smart00349
    Location:90 → 132
    KRAB; krueppel associated box
    COG5048
    Location:178 → 436
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:364 → 384
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:90 → 129
    KRAB; KRAB box
    pfam13465
    Location:264 → 288
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247099962..247104356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    246531595..246535990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BR6.2 GenPept UniProtKB/Swiss-Prot:Q96BR6

Gene LinkOut

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