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EPHX3 epoxide hydrolase 3 [ Homo sapiens (human) ]

Gene ID: 79852, updated on 5-Mar-2024

Summary

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Official Symbol
EPHX3provided by HGNC
Official Full Name
epoxide hydrolase 3provided by HGNC
Primary source
HGNC:HGNC:23760
See related
Ensembl:ENSG00000105131 MIM:617400; AllianceGenome:HGNC:23760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EH3; ABHD9
Summary
Enables epoxide hydrolase activity. Involved in epoxide metabolic process. Located in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 21.8), esophagus (RPKM 15.1) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
19p13.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15226919..15237008, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15351830..15358380, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15337730..15343779, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 782, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15281145-15281735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10267 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15291996-15292515 Neighboring gene notch receptor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15292516-15293034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15296283-15296783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15305376-15305876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15305877-15306377 Neighboring gene microRNA 6795 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:15310876-15311102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15311689-15312190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15312191-15312690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15333321-15334017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15343009-15343510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15361355-15362226 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:15373316-15373494 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:15374509-15375008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15376180-15376680 Neighboring gene bromodomain containing 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:15385287-15385786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14183 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15409795-15410322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15410749-15411456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10274 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:15443616-15444232 Neighboring gene uncharacterized LOC124904643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14184 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:15489739-15490654 and GRCh37_chr19:15490655-15491569 Neighboring gene A-kinase anchoring protein 8 Neighboring gene A-kinase anchoring protein 8 like Neighboring gene NANOG hESC enhancer GRCh37_chr19:15523607-15524136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15524849-15525350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15525351-15525850

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence. Stott-Miller M, et al. Cancer Epidemiol Biomarkers Prev, 2014 Jul. PMID 24718283, Free PMC Article
  2. Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis. Cottrell S, et al. J Urol, 2007 May. PMID 17437806
  3. Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. Morisseau C, et al. Int J Mol Sci, 2021 May 8. PMID 34066758, Free PMC Article
  4. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Decker M, et al. J Lipid Res, 2012 Oct. PMID 22798687, Free PMC Article
  5. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. Bagryantseva Y, et al. Toxicol Lett, 2010 Nov 10. PMID 20723587

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues.
    Title: Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues.
  2. These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence
    Title: Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence.
  3. The identification of two human epoxide hydrolases: EH3 and EH4.
    Title: EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.
  5. methylation of the ABHD9 is significantly associated with prostate cancer prognosis.
    Title: Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ22408, MGC131519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables epoxide hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
epoxide hydrolase 3
Names
abhydrolase domain containing 9
abhydrolase domain-containing protein 9
NP_001136358.1
NP_079070.1
XP_024307493.1
XP_047295408.1
XP_054178167.1
XP_054178168.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142886.2 → NP_001136358.1  epoxide hydrolase 3

    See identical proteins and their annotated locations for NP_001136358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5'UTR. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004257, BC115002, CD632298, DA378406
    Consensus CDS
    CCDS12327.1
    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9
    Related
    ENSP00000410323.1, ENST00000435261.5
    Conserved Domains (1) summary
    COG0596
    Location:80 → 351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. NM_024794.3 → NP_079070.1  epoxide hydrolase 3

    See identical proteins and their annotated locations for NP_079070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) has an alternate 5'UTR. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC004257, AK026061, BC115002
    Consensus CDS
    CCDS12327.1
    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9
    Related
    ENSP00000221730.2, ENST00000221730.8
    Conserved Domains (1) summary
    COG0596
    Location:80 → 351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    15226919..15237008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439452.1 → XP_047295408.1  epoxide hydrolase 3 isoform X1

    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9

  2. XM_024451725.2 → XP_024307493.1  epoxide hydrolase 3 isoform X1

    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9
    Related
    ENSP00000469345.1, ENST00000602233.5
    Conserved Domains (1) summary
    COG0596
    Location:80 → 351
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    15351830..15358380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322193.1 → XP_054178168.1  epoxide hydrolase 3 isoform X1

    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9

  2. XM_054322192.1 → XP_054178167.1  epoxide hydrolase 3 isoform X1

    UniProtKB/Swiss-Prot
    A3KMR3, Q9H6B9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6B9.1 GenPept UniProtKB/Swiss-Prot:Q9H6B9

Gene LinkOut

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