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MOB3B MOB kinase activator 3B [ Homo sapiens (human) ]

Gene ID: 79817, updated on 5-Mar-2024

Summary

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Official Symbol
MOB3Bprovided by HGNC
Official Full Name
MOB kinase activator 3Bprovided by HGNC
Primary source
HGNC:HGNC:23825
See related
Ensembl:ENSG00000120162 MIM:617652; AllianceGenome:HGNC:23825
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1D; C9orf35; MOBKL2B
Summary
The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 14.2), duodenum (RPKM 9.8) and 20 other tissues See more
Orthologs
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Genomic context

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Location:
9p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (27325209..27529814, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (27335803..27540380, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27325207..27529812, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251147-27251648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27251649-27252148 Neighboring gene long intergenic non-protein coding RNA 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27279903-27280404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27303550-27304050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27304051-27304551 Neighboring gene equatorin Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:27353610-27354591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28253 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:27369079-27369832 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:27369833-27370587 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:27395570-27396133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27465247-27465748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:27494687-27495392 Neighboring gene dapper homolog 3-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19821 Neighboring gene Sharpr-MPRA regulatory region 13504 Neighboring gene interferon kappa Neighboring gene C9orf72-SMCR8 complex subunit Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19822 Neighboring gene chromosome 9 open reading frame 72 repeat instability region Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:27573561-27574088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:27610369-27610870 Neighboring gene CTAGE family member 12, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics. Kim EA, et al. J Korean Med Sci, 2015 Jul. PMID 26130958, Free PMC Article
  2. A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. Kerns SL, et al. J Urol, 2013 Jul. PMID 23376709
  3. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Joung J, et al. Nature, 2017 Aug 17. PMID 28792927, Free PMC Article
  4. Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study. Suarez-Gestal M, et al. Arthritis Res Ther, 2010. PMID 20423481, Free PMC Article
  5. Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Liu C, et al. Mol Med, 2008 Sep-Oct. PMID 18615156, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. low levels of hMOB3B are closely associated with aggressive clinicopathologic features in patients with prostate cancer. The results suggest that hMOB3B may act as a tumor suppressor in human prostate cancer.
    Title: Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.
EBI GWAS Catalog
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13204, FLJ23916, MGC32960

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 3B
Names
MOB kinase activator-like 2B
MOB1, Mps One Binder kinase activator-like 2B
mob1 homolog 2b
monopolar spindle 1 binding, MOB1, domain containing
mps one binder kinase activator-like 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024761.5 → NP_079037.3  MOB kinase activator 3B

    See identical proteins and their annotated locations for NP_079037.3

    Status: REVIEWED

    Source sequence(s)
    AK023266, AL163192, BF511468, CN260547, DB266074
    Consensus CDS
    CCDS6520.1
    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4
    Related
    ENSP00000262244.5, ENST00000262244.6
    Conserved Domains (1) summary
    pfam03637
    Location:35 → 207
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    27325209..27529814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423892.1 → XP_047279848.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  2. XM_047423895.1 → XP_047279851.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  3. XM_047423894.1 → XP_047279850.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  4. XM_047423891.1 → XP_047279847.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  5. XM_047423893.1 → XP_047279849.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    27335803..27540380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363858.1 → XP_054219833.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  2. XM_054363860.1 → XP_054219835.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  3. XM_054363857.1 → XP_054219832.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4

  4. XM_054363859.1 → XP_054219834.1  MOB kinase activator 3B isoform X1

    UniProtKB/Swiss-Prot
    Q86TA1, Q8NEB4, Q9H8V4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86TA1.2 GenPept UniProtKB/Swiss-Prot:Q86TA1

Gene LinkOut

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