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GSTCD glutathione S-transferase C-terminal domain containing [ Homo sapiens (human) ]

Gene ID: 79807, updated on 5-Mar-2024

Summary

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Official Symbol
GSTCDprovided by HGNC
Official Full Name
glutathione S-transferase C-terminal domain containingprovided by HGNC
Primary source
HGNC:HGNC:25806
See related
Ensembl:ENSG00000138780 MIM:615912; AllianceGenome:HGNC:25806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs
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Genomic context

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See GSTCD in Genome Data Viewer
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (105708784..105847725)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (109019919..109158852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (106629941..106768882)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900748 Neighboring gene uncharacterized LOC124900747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21784 Neighboring gene integrator complex subunit 12 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:106703288-106703493 Neighboring gene uncharacterized LOC107986190 Neighboring gene GSTCD antisense RNA 1 Neighboring gene uncharacterized LOC124900749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15611 Neighboring gene Sharpr-MPRA regulatory region 231 Neighboring gene nephronectin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:106919539-106920322 Neighboring gene uncharacterized LOC101929577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Defining a role for lung function associated gene GSTCD in cell homeostasis. Henry AP, et al. Respir Res, 2019 Aug 1. PMID 31370853, Free PMC Article
  2. Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study. Levinsson A, et al. PLoS One, 2014. PMID 24915237, Free PMC Article
  3. GSTCD and INTS12 regulation and expression in the human lung. Obeidat M, et al. PLoS One, 2013. PMID 24058608, Free PMC Article
  4. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Soler Artigas M, et al. Am J Respir Crit Care Med, 2011 Oct 1. PMID 21965014, Free PMC Article
  5. Genome-wide association study identifies five loci associated with lung function. Repapi E, et al. Nat Genet, 2010 Jan. PMID 20010834, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted knock-down of GSTCD in bronchial epithelial cells identified a role for GSTCD in cell viability.
    Title: Defining a role for lung function associated gene GSTCD in cell homeostasis.
  2. Air pollution exposure entails an increased risk of acute myocardial infarction, and this risk differed over genotype strata for variants in the GSTP1, GSTT1 and GSTCD genes, albeit not statistically-significantly.
    Title: Interaction effects of long-term air pollution exposure and variants in the GSTP1, GSTT1 and GSTCD genes on risk of acute myocardial infarction and hypertension: a case-control study.
  3. In fixed sections of human lung tissue, GSTCD protein expression was ubiquitous, whereas INTS12 expression was predominantly in epithelial cells and pneumocytes.
    Title: GSTCD and INTS12 regulation and expression in the human lung.
  4. GSTCD polymorphism associated with COPD risk and lung function decline
    Title: Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
  6. Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease.
    Title: Genome-wide association study identifies five loci associated with lung function.
  7. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
EBI GWAS Catalog
Genome-wide association study identifies five loci associated with lung function.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13273, DKFZp686I10174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
glutathione S-transferase C-terminal domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031720.3 → NP_001026890.2  glutathione S-transferase C-terminal domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001026890.2

    Status: VALIDATED

    Source sequence(s)
    AC008243, AK292355, BC032942
    Consensus CDS
    CCDS43257.1
    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
    Related
    ENSP00000353695.5, ENST00000360505.9
    Conserved Domains (2) summary
    cl02776
    Location:270 → 329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423 → 541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001370181.1 → NP_001357110.1  glutathione S-transferase C-terminal domain-containing protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008243, AC105391
    Consensus CDS
    CCDS43257.1
    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
    Related
    ENSP00000422354.1, ENST00000515279.6
    Conserved Domains (2) summary
    cl02776
    Location:270 → 329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423 → 541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_024751.3 → NP_079027.2  glutathione S-transferase C-terminal domain-containing protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008243, AK303547, BC032942, BX648355
    Consensus CDS
    CCDS3672.2
    UniProtKB/Swiss-Prot
    Q8NEC7
    UniProtKB/TrEMBL
    B7Z8J7
    Related
    ENSP00000378218.3, ENST00000394730.7
    Conserved Domains (2) summary
    cl02776
    Location:186 → 242
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:336 → 454
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    105708784..105847725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532252.4 → XP_011530554.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530554.1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
    Conserved Domains (2) summary
    cl02776
    Location:270 → 329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423 → 541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_047416179.1 → XP_047272135.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

  3. XM_011532248.4 → XP_011530550.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530550.1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
    Conserved Domains (2) summary
    cl02776
    Location:270 → 329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423 → 541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_011532249.4 → XP_011530551.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011530551.1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3
    Conserved Domains (2) summary
    cl02776
    Location:270 → 329
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    cl17173
    Location:423 → 541
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_938771.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    109019919..109158852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350844.1 → XP_054206819.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

  2. XM_054350845.1 → XP_054206820.1  glutathione S-transferase C-terminal domain-containing protein isoform X2

  3. XM_054350842.1 → XP_054206817.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

  4. XM_054350843.1 → XP_054206818.1  glutathione S-transferase C-terminal domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    A8K8J0, A8MVD3, H9KV97, Q8NEC7, Q9H8S3

RNA

  1. XR_008487031.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEC7.2 GenPept UniProtKB/Swiss-Prot:Q8NEC7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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