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hbegfa heparin-binding EGF-like growth factor a [ Danio rerio (zebrafish) ]

Gene ID: 797938, updated on 28-Oct-2024

Summary

Official Symbol
hbegfaprovided by ZNC
Official Full Name
heparin-binding EGF-like growth factor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-119
See related
Ensembl:ENSDARG00000075121 AllianceGenome:ZFIN:ZDB-GENE-080204-119
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:175091
Summary
Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Acts upstream of or within response to wounding; retina development in camera-type eye; and sensory epithelium regeneration. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in retina. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

See hbegfa in Genome Data Viewer
Location:
chromosome: 14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7048993..7051940)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (6742266..6745213)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E binding protein 3, like Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene si:ch73-43g23.1 Neighboring gene tRNA phosphotransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heparin-binding EGF-like growth factor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111226.1NP_001104696.1  heparin-binding EGF-like growth factor a precursor

    See identical proteins and their annotated locations for NP_001104696.1

    Status: PROVISIONAL

    Source sequence(s)
    BC155826
    UniProtKB/TrEMBL
    A0A8N1YYX8, A9JRW9
    Related
    ENSDARP00000099541.3, ENSDART00000109138.4
    Conserved Domains (1) summary
    PHA02887
    Location:130170
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    7048993..7051940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)