jam3a junctional adhesion molecule 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jam3aprovided by ZNC
Official Full Name: junctional adhesion molecule 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070424-177
See related: Ensembl:ENSDARG00000114589 AllianceGenome:ZFIN:ZDB-GENE-070424-177
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jamc.2; si:ch211-277g22.3
Summary: Predicted to enable cell-cell adhesion mediator activity and integrin binding activity. Predicted to be involved in cell migration and cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be part of protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Is expressed in brain; lateral line primordium; and neural tube. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (19293849..19317134)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (19358091..19381568)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The studies demonstrate that although Jamb, Jamc, and Mymk are all involved in myoblast fusion during early myogenesis, they have distinct roles in myoblast fusion during muscle growth. While Mymk is essential for myoblast fusion during both muscle development and growth, Jamb and Jamc are dispensable for myoblast fusion during muscle growth.
Title: Genetic Mutations in jamb, jamc, and myomaker Revealed Different Roles on Myoblast Fusion and Muscle Growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: junctional adhesion molecule C

Names: JAM-C-like protein; jamc2; junctional adhesion molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

19293849..19317134

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466393.2 → XP_021322068.1 junctional adhesion molecule C

UniProtKB/TrEMBL

A0A8M9P779, F1QYW3

Related

ENSDARP00000105600.2, ENSDART00000123815.3

Conserved Domains (2) summary

smart00409
Location:31 → 109

IG; Immunoglobulin

pfam13927
Location:130 → 215

Ig_3; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394945.1 Reference GRCz11 ALT_DRER_TU_1

Range

197018..220236

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001338087.8 → XP_001338123.2 junctional adhesion molecule C

UniProtKB/TrEMBL

A0A8M1Q7B3

Conserved Domains (2) summary

smart00409
Location:31 → 109

IG; Immunoglobulin

pfam13927
Location:130 → 215

Ig_3; Immunoglobulin domain