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ZNF385D zinc finger protein 385D [ Homo sapiens (human) ]

Gene ID: 79750, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF385Dprovided by HGNC
Official Full Name
zinc finger protein 385Dprovided by HGNC
Primary source
HGNC:HGNC:26191
See related
Ensembl:ENSG00000151789 AllianceGenome:HGNC:26191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF659
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 1.9), brain (RPKM 1.5) and 16 other tissues See more
Orthologs
all
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Genomic context

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See ZNF385D in Genome Data Viewer
Location:
3p24.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (21412218..22372763, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (21422674..21761443, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (21453710..21792702, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376988 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:21245759-21245949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:21440269-21440769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:21447352-21447855 Neighboring gene VENT homeobox pseudogene 7 Neighboring gene NANOG hESC enhancer GRCh37_chr3:21558661-21559162 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:21584849-21585429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:21589175-21589999 Neighboring gene ZNF385D antisense RNA 1 Neighboring gene MPRA-validated peak4572 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68017 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68021 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68035 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68037 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68058 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68089 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68153 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68192 Neighboring gene ZNF385D antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:22029852-22030429 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68287 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68298 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_68318 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:22347885-22348477 Neighboring gene high mobility group box 1 pseudogene 5 Neighboring gene FCRL4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study of shared components of reading disability and language impairment. Eicher JD, et al. Genes Brain Behav, 2013 Nov. PMID 24024963, Free PMC Article
  2. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Kasperaviciūte D, et al. Brain, 2010 Jul. PMID 20522523, Free PMC Article
  3. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Ferreira MA, et al. Nat Genet, 2008 Sep. PMID 18711365, Free PMC Article
  4. Host determinants of HIV-1 control in African Americans. Pelak K, et al. J Infect Dis, 2010 Apr 15. PMID 20205591, Free PMC Article
  5. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. Velez Edwards DR, et al. Hum Genet, 2013 Mar. PMID 23192594, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF385D is a candidate gene for reading disability and language impairment.
    Title: Genome-wide association study of shared components of reading disability and language impairment.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
EBI GWAS Catalog
Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.
EBI GWAS Catalog
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
EBI GWAS Catalog
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Host determinants of HIV-1 control in African Americans.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 385D
Names
zinc finger protein 659

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024697.3 → NP_078973.1  zinc finger protein 385D

    See identical proteins and their annotated locations for NP_078973.1

    Status: VALIDATED

    Source sequence(s)
    AC104183, AK026072
    Consensus CDS
    CCDS2636.1
    UniProtKB/Swiss-Prot
    Q9H6B1
    Related
    ENSP00000281523.2, ENST00000281523.8
    Conserved Domains (2) summary
    sd00020
    Location:206 → 228
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:267 → 291
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    21412218..22372763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007192.2 → XP_016862681.1  zinc finger protein 385D isoform X2

    UniProtKB/TrEMBL
    A0A2R8YG37
    Related
    ENSP00000495609.3, ENST00000494108.3
    Conserved Domains (2) summary
    sd00020
    Location:307 → 329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:368 → 392
    zf-met; Zinc-finger of C2H2 type

  2. XM_017007191.2 → XP_016862680.1  zinc finger protein 385D isoform X1

    UniProtKB/TrEMBL
    A0A994J5P6
    Related
    ENSP00000516216.1, ENST00000706131.1
    Conserved Domains (2) summary
    sd00020
    Location:326 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:388 → 411
    zf-met; Zinc-finger of C2H2 type

  3. XM_017007199.2 → XP_016862688.1  zinc finger protein 385D isoform X12

    Conserved Domains (2) summary
    sd00020
    Location:173 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:235 → 258
    zf-met; Zinc-finger of C2H2 type

  4. XM_047448956.1 → XP_047304912.1  zinc finger protein 385D isoform X4

  5. XM_047448960.1 → XP_047304916.1  zinc finger protein 385D isoform X11

  6. XM_017007198.2 → XP_016862687.1  zinc finger protein 385D isoform X9

  7. XM_017007195.2 → XP_016862684.1  zinc finger protein 385D isoform X5

    Conserved Domains (2) summary
    sd00020
    Location:240 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:302 → 325
    zf-met; Zinc-finger of C2H2 type

  8. XM_047448958.1 → XP_047304914.1  zinc finger protein 385D isoform X8

  9. XM_017007193.2 → XP_016862682.1  zinc finger protein 385D isoform X3

    Conserved Domains (2) summary
    sd00020
    Location:255 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:317 → 340
    zf-met; Zinc-finger of C2H2 type

  10. XM_017007196.2 → XP_016862685.1  zinc finger protein 385D isoform X6

    Conserved Domains (2) summary
    sd00020
    Location:225 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:287 → 310
    zf-met; Zinc-finger of C2H2 type

  11. XM_017007197.2 → XP_016862686.1  zinc finger protein 385D isoform X7

  12. XM_047448959.1 → XP_047304915.1  zinc finger protein 385D isoform X10

    UniProtKB/TrEMBL
    A0A994J524
    Related
    ENSP00000516219.1, ENST00000706134.1

  13. XM_017007200.3 → XP_016862689.1  zinc finger protein 385D isoform X13

    Conserved Domains (2) summary
    sd00020
    Location:170 → 192
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:232 → 255
    zf-met; Zinc-finger of C2H2 type

  14. XM_017007201.2 → XP_016862690.1  zinc finger protein 385D isoform X14

    Conserved Domains (2) summary
    sd00020
    Location:112 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:174 → 197
    zf-met; Zinc-finger of C2H2 type

  15. XM_017007202.2 → XP_016862691.1  zinc finger protein 385D isoform X16

    Conserved Domains (2) summary
    sd00020
    Location:73 → 95
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:135 → 158
    zf-met; Zinc-finger of C2H2 type

  16. XM_011534122.3 → XP_011532424.1  zinc finger protein 385D isoform X15

    See identical proteins and their annotated locations for XP_011532424.1

    Conserved Domains (2) summary
    sd00020
    Location:183 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:70 → 92
    zf-met; Zinc-finger of C2H2 type

  17. XM_011534124.4 → XP_011532426.1  zinc finger protein 385D isoform X15

    See identical proteins and their annotated locations for XP_011532426.1

    Conserved Domains (2) summary
    sd00020
    Location:183 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:70 → 92
    zf-met; Zinc-finger of C2H2 type

  18. XM_017007203.2 → XP_016862692.1  zinc finger protein 385D isoform X17

  19. XM_011534123.3 → XP_011532425.1  zinc finger protein 385D isoform X15

    See identical proteins and their annotated locations for XP_011532425.1

    Conserved Domains (2) summary
    sd00020
    Location:183 → 205
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:70 → 92
    zf-met; Zinc-finger of C2H2 type

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    21422674..21761443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6B1.1 GenPept UniProtKB/Swiss-Prot:Q9H6B1

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