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st6gal2b ST6 beta-galactosamide alpha-2,6-sialyltranferase 2b [ Danio rerio (zebrafish) ]

Gene ID: 797439, updated on 12-Sep-2024

Summary

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Official Symbol
st6gal2bprovided by ZNC
Official Full Name
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120426-2
See related
Ensembl:ENSDARG00000088515 AllianceGenome:ZFIN:ZDB-GENE-120426-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SIAT2-r; st6gal2l; st6gal2-r
Summary
Predicted to enable beta-galactoside alpha-2,6-sialyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; gut; hatching gland; integument; and pleuroperitoneal region. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See st6gal2b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (15436317..15491584, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (15310195..15364911, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene otospiralin 2 Neighboring gene ECRG4 augurin precursor b Neighboring gene teleost multiple tissue opsin 2a Neighboring gene leucine rich repeat (in FLII) interacting protein 1b Neighboring gene melanophilin a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. Petit D, et al. J Biol Chem, 2010 Dec 3. PMID 20855889, Free PMC Article
  2. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757
  3. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Yamakawa N, et al. Nat Commun, 2018 Nov 7. PMID 30405127, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside alpha-2,6-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-galactoside alpha-2,6-sialyltransferase 2b
Names
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2, like
alpha-2,6-sialyltransferase ST6Gal IIB
NP_001164692.1
XP_005168774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171221.1 → NP_001164692.1  beta-galactoside alpha-2,6-sialyltransferase 2b

    See identical proteins and their annotated locations for NP_001164692.1

    Status: PROVISIONAL

    Source sequence(s)
    FN550105
    UniProtKB/TrEMBL
    A0A8M2BG06, D2U4T9
    Conserved Domains (1) summary
    pfam00777
    Location:217 → 443
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    15436317..15491584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168717.5 → XP_005168774.1  beta-galactoside alpha-2,6-sialyltransferase 2b isoform X1

    See identical proteins and their annotated locations for XP_005168774.1

    UniProtKB/TrEMBL
    A0A8M2BG06, D2U4T9
    Related
    ENSDARP00000129467.1, ENSDART00000156439.2
    Conserved Domains (1) summary
    pfam00777
    Location:217 → 443
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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