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NLRX1 NLR family member X1 [ Homo sapiens (human) ]

Gene ID: 79671, updated on 7-Apr-2024

Summary

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Official Symbol
NLRX1provided by HGNC
Official Full Name
NLR family member X1provided by HGNC
Primary source
HGNC:HGNC:29890
See related
Ensembl:ENSG00000160703 MIM:611947; AllianceGenome:HGNC:29890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOD5; NOD9; NOD26; DLNB26; CLR11.3
Summary
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in esophagus (RPKM 15.5), skin (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (119168334..119184016)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (119188702..119204385)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119039043..119054725)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3970 Neighboring gene histone H4 transcription factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3971 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119027357-119027857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:119029281-119029780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119039524-119040229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:119040230-119040934 Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene small nucleolar RNA, C/D box 150 Neighboring gene dynein regulatory complex subunit 12 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation. Wang Q, et al. Allergol Immunopathol (Madr), 2023. PMID 36617838
  2. The regulatory role of NLRX1 in innate immunity and human disease. Liu M, et al. Cytokine, 2022 Dec. PMID 36194971
  3. NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells. Jiao Q, et al. Sci Prog, 2021 Oct. PMID 34825857, Free PMC Article
  4. Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific. Kastelberg B, et al. Front Immunol, 2021. PMID 34790195, Free PMC Article
  5. Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation. Koo JH, et al. Biomaterials, 2021 Jul. PMID 33971559

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
    Title: NLRX1: Versatile functions of a mitochondrial NLR protein that controls mitophagy.
  2. NLRX1 increases human retinal pigment epithelial autophagy and reduces H2O2-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
    Title: NLRX1 increases human retinal pigment epithelial autophagy and reduces H(2)O(2)-induced oxidative stress and inflammation by suppressing FUNDC1 phosphorylation and NLRP3 activation.
  3. The regulatory role of NLRX1 in innate immunity and human disease.
    Title: The regulatory role of NLRX1 in innate immunity and human disease.
  4. NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
    Title: NLRX1 can counteract innate immune response induced by an external stimulus favoring HBV infection by competitive inhibition of MAVS-RLRs signaling in HepG2-NTCP cells.
  5. Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
    Title: Nlrx1-Regulated Defense and Metabolic Responses to Aspergillus fumigatus Are Morphotype and Cell Type Specific.
  6. MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
    Title: MicroRNA-195 suppresses enterovirus A71-induced pyroptosis in human neuroblastoma cells through targeting NLRX1.
  7. Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
    Title: Focusing on the Cell Type Specific Regulatory Actions of NLRX1.
  8. Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
    Title: Behind the Scenes: Nod-Like Receptor X1 Controls Inflammation and Metabolism.
  9. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
    Title: Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
  10. Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-kappaB and inflammasome signaling activation.
    Title: Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of NLR family member X1 (NLRX1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21478, MGC21025, MGC131937

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of RIG-I signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
NLR family member X1
Names
NOD-like receptor X1
caterpiller protein 11.3
nucleotide-binding oligomerization domain protein 26
nucleotide-binding oligomerization domain protein 5
nucleotide-binding oligomerization domain protein 9
nucleotide-binding oligomerization domain, leucine rich repeat containing X1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047185.1 RefSeqGene

    Range
    5392..20683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282143.2 → NP_001269072.1  NLR family member X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001269072.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
    Source sequence(s)
    AB094095, BX647705, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Related
    ENSP00000386851.1, ENST00000409991.5
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001282144.2 → NP_001269073.1  NLR family member X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001269073.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AB094095, BC110890, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Related
    ENSP00000387334.1, ENST00000409109.6
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001282358.2 → NP_001269287.1  NLR family member X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001269287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. All variants encode the same protein.
    Source sequence(s)
    AB094095, AP002956, DA441499
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_024618.4 → NP_078894.2  NLR family member X1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_078894.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. All three variants encode the same protein.
    Source sequence(s)
    AB094095, DA107044
    Consensus CDS
    CCDS8416.1
    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Related
    ENSP00000292199.2, ENST00000292199.6
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_170722.2 → NP_733840.1  NLR family member X1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AP002956
    Consensus CDS
    CCDS44752.1
    UniProtKB/TrEMBL
    A0A9L9PXS9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    119168334..119184016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542980.2 → XP_011541282.1  NLR family member X1 isoform X1

    See identical proteins and their annotated locations for XP_011541282.1

    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006718904.2 → XP_006718967.1  NLR family member X1 isoform X2

    UniProtKB/TrEMBL
    A0A9L9PXS9
    Conserved Domains (3) summary
    cd00116
    Location:698 → 850
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:698 → 726
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_005271669.2 → XP_005271726.1  NLR family member X1 isoform X1

    See identical proteins and their annotated locations for XP_005271726.1

    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724
    UniProtKB/TrEMBL
    A0A9L9PXS9
    Related
    ENSP00000516519.1, ENST00000706729.1
    Conserved Domains (3) summary
    cd00116
    Location:698 → 885
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_047427586.1 → XP_047283542.1  NLR family member X1 isoform X2

  5. XM_047427587.1 → XP_047283543.1  NLR family member X1 isoform X2

    Related
    ENSP00000433442.1, ENST00000525863.1

  6. XM_047427589.1 → XP_047283545.1  NLR family member X1 isoform X3

    UniProtKB/TrEMBL
    A0A9L9PX86
    Related
    ENSP00000516517.1, ENST00000706728.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    119188702..119204385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369945.1 → XP_054225920.1  NLR family member X1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

  2. XM_054369944.1 → XP_054225919.1  NLR family member X1 isoform X1

    UniProtKB/Swiss-Prot
    A8K6Q1, B3KPK2, B3KTA2, Q7RTR3, Q86UT6, Q96D51, Q9H724

  3. XM_054369946.1 → XP_054225921.1  NLR family member X1 isoform X2

  4. XM_054369947.1 → XP_054225922.1  NLR family member X1 isoform X2

  5. XM_054369948.1 → XP_054225923.1  NLR family member X1 isoform X2

  6. XM_054369949.1 → XP_054225924.1  NLR family member X1 isoform X3

    UniProtKB/TrEMBL
    A0A9L9PX86
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UT6.1 GenPept UniProtKB/Swiss-Prot:Q86UT6

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