prepl prolyl endopeptidase like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: preplprovided by ZNC
Official Full Name: prolyl endopeptidase likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-224
See related: Ensembl:ENSDARG00000017853 AllianceGenome:ZFIN:ZDB-GENE-090313-224
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-202m23.1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in Golgi apparatus and cytoskeleton. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 22. Orthologous to human PREPL (prolyl endopeptidase like). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (10621257..10647182)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (10488764..10514707)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolyl endopeptidase-like

NP_001139088.1

EC 3.4.21.-

XP_005156632.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145616.1 → NP_001139088.1 prolyl endopeptidase-like

Status: PROVISIONAL

Source sequence(s)

CT030019

UniProtKB/TrEMBL

A0A8M1NRM5, B8JJX2

Related

ENSDARP00000010838.7, ENSDART00000008603.9

Conserved Domains (2) summary

COG1770
Location:167 → 680

PtrB; Protease II [Amino acid transport and metabolism]

cl21494
Location:454 → 681

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

10621257..10647182

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156575.5 → XP_005156632.1 prolyl endopeptidase-like isoform X1

UniProtKB/TrEMBL

A0A8M2B2W4

Conserved Domains (2) summary

COG1770
Location:167 → 625

PtrB; Protease II [Amino acid transport and metabolism]

cl21494
Location:454 → 627

Abhydrolase; alpha/beta hydrolases