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HECTD3 HECT domain E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 79654, updated on 5-Mar-2024

Summary

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Official Symbol
HECTD3provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:26117
See related
Ensembl:ENSG00000126107 MIM:618638; AllianceGenome:HGNC:26117
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]
Expression
Ubiquitous expression in duodenum (RPKM 25.9), small intestine (RPKM 22.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45002548..45011324, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44874147..44882918, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45468220..45476996, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 35 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45479433-45479969 Neighboring gene zinc finger SWIM-type containing 5 Neighboring gene uroporphyrinogen decarboxylase Neighboring gene oligosaccharyltransferase complex subunit pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of E3 ubiquitin ligase HECTD3 in cancer and beyond. Jiang Q, et al. Cell Mol Life Sci, 2020 Apr. PMID 31637449
  2. HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients. Li Z, et al. Cell Rep, 2017 Jun 20. PMID 28636940, Free PMC Article
  3. HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway. Zhang G, et al. Br J Cancer, 2022 Nov. PMID 36088509, Free PMC Article
  4. HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC. Zhang G, et al. Cell Death Discov, 2022 Apr 9. PMID 35397617, Free PMC Article
  5. The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8. Li Y, et al. Cell Death Dis, 2013 Nov 28. PMID 24287696, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.
    Title: E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer.
  2. HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
    Title: HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
  3. This review describes the progress in the recent studies of HECTD3 in cancer and other diseases. [review]
    Title: The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.
  4. HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway.
    Title: HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
  5. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis.
    Title: The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.
  6. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara.
    Title: The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21156, FLJ31983, MGC161630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD3
Names
HECT domain containing E3 ubiquitin protein ligase 3
HECT-type E3 ubiquitin transferase HECTD3
NP_078878.3
XP_047286443.1
XP_054194713.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033058.1 RefSeqGene

    Range
    5032..13808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024602.6 → NP_078878.3  E3 ubiquitin-protein ligase HECTD3

    See identical proteins and their annotated locations for NP_078878.3

    Status: REVIEWED

    Source sequence(s)
    AK056545, AK056873, AK096462, AL359473, DA332198
    Consensus CDS
    CCDS41318.1
    UniProtKB/Swiss-Prot
    B3KPV7, B3KRH4, Q5T447, Q5T448, Q9H783
    UniProtKB/TrEMBL
    B4DVK6
    Related
    ENSP00000361245.4, ENST00000372172.5
    Conserved Domains (2) summary
    cd08666
    Location:238 → 371
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    pfam00632
    Location:579 → 845
    HECT; HECT-domain (ubiquitin-transferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    45002548..45011324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430487.1 → XP_047286443.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

    UniProtKB/TrEMBL
    A1A4G1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    44874147..44882918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338738.1 → XP_054194713.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

    UniProtKB/TrEMBL
    A1A4G1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T447.1 GenPept UniProtKB/Swiss-Prot:Q5T447

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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