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CCNJL cyclin J like [ Homo sapiens (human) ]

Gene ID: 79616, updated on 3-Apr-2024

Summary

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Official Symbol
CCNJLprovided by HGNC
Official Full Name
cyclin J likeprovided by HGNC
Primary source
HGNC:HGNC:25876
See related
Ensembl:ENSG00000135083 AllianceGenome:HGNC:25876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.2), lung (RPKM 2.2) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
5q33.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160249083..160339570, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160777639..160868099, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159676090..159766577, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene MPRA-validated peak5557 silencer Neighboring gene PWWP domain containing 2A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159588248-159588903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159589561-159590215 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159591897-159592496 Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:159593698-159594298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159602660-159603248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16579 Neighboring gene MPRA-validated peak5559 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16580 Neighboring gene FABP6 antisense RNA 1 Neighboring gene fatty acid binding protein 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16581 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159664401-159665356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23558 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159705762-159706289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159713163-159713896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159712429-159713162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159715411-159716388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16583 Neighboring gene SNRPE pseudogene 1 Neighboring gene C1q and TNF related 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159825203-159825702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159826022-159826707 Neighboring gene family with sequence similarity 200 member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive Analysis of Cyclin Family Gene Expression in Colon Cancer. Li J, et al. Front Oncol, 2021. PMID 33996604, Free PMC Article
  2. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  3. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-J-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308173.3 → NP_001295102.1  cyclin-J-like protein isoform b

    See identical proteins and their annotated locations for NP_001295102.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC112191, AK302823, BC013353, BF111450
    Consensus CDS
    CCDS78082.1
    UniProtKB/TrEMBL
    B4DZA8, B5MDN2
    Related
    ENSP00000257536.7, ENST00000257536.13
    Conserved Domains (2) summary
    pfam02984
    Location:145 → 247
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:14 → 107
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

  2. NM_024565.8 → NP_078841.3  cyclin-J-like protein isoform a

    See identical proteins and their annotated locations for NP_078841.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC112191, BC013353, BC035871, BF111450
    Consensus CDS
    CCDS4350.2
    UniProtKB/Swiss-Prot
    Q6ZN43, Q8IV13, Q9H7W8
    Related
    ENSP00000377547.3, ENST00000393977.7
    Conserved Domains (2) summary
    pfam02984
    Location:193 → 295
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:14 → 93
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_131769.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112191, AK131381, AK294000, BF111450

  2. NR_177110.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC112191

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    160249083..160339570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534646.4 → XP_011532948.1  cyclin-J-like protein isoform X5

    See identical proteins and their annotated locations for XP_011532948.1

    Conserved Domains (1) summary
    pfam02984
    Location:123 → 230
    Cyclin_C; Cyclin, C-terminal domain

  2. XM_017009847.2 → XP_016865336.2  cyclin-J-like protein isoform X3

  3. XM_006714917.5 → XP_006714980.1  cyclin-J-like protein isoform X1

    Conserved Domains (2) summary
    cd00043
    Location:35 → 90
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam02984
    Location:190 → 292
    Cyclin_C; Cyclin, C-terminal domain

  4. XM_047417702.1 → XP_047273658.1  cyclin-J-like protein isoform X4

  5. XM_047417704.1 → XP_047273660.1  cyclin-J-like protein isoform X7

  6. XM_011534647.4 → XP_011532949.1  cyclin-J-like protein isoform X6

    Conserved Domains (1) summary
    pfam02984
    Location:87 → 189
    Cyclin_C; Cyclin, C-terminal domain

  7. XM_047417701.1 → XP_047273657.1  cyclin-J-like protein isoform X2

    Related
    ENSP00000427960.1, ENST00000519673.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    160777639..160868099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353446.1 → XP_054209421.1  cyclin-J-like protein isoform X5

  2. XM_054353443.1 → XP_054209418.1  cyclin-J-like protein isoform X3

  3. XM_054353441.1 → XP_054209416.1  cyclin-J-like protein isoform X1

  4. XM_054353444.1 → XP_054209419.1  cyclin-J-like protein isoform X4

  5. XM_054353447.1 → XP_054209422.1  cyclin-J-like protein isoform X7

  6. XM_054353445.1 → XP_054209420.1  cyclin-J-like protein isoform X6

  7. XM_054353442.1 → XP_054209417.1  cyclin-J-like protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IV13.3 GenPept UniProtKB/Swiss-Prot:Q8IV13

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