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ADIPOR2 adiponectin receptor 2 [ Homo sapiens (human) ]

Gene ID: 79602, updated on 5-Mar-2024

Summary

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Official Symbol
ADIPOR2provided by HGNC
Official Full Name
adiponectin receptor 2provided by HGNC
Primary source
HGNC:HGNC:24041
See related
Ensembl:ENSG00000006831 MIM:607946; AllianceGenome:HGNC:24041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAQR2; ACDCR2
Summary
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in fat (RPKM 49.9), adrenal (RPKM 34.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ADIPOR2 in Genome Data Viewer
Location:
12p13.33
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (1691070..1788674)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (1687685..1784807)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1800236..1897840)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4116 Neighboring gene Sharpr-MPRA regulatory region 3814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1755758-1756258 Neighboring gene Wnt family member 5B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1756259-1756759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5809 Neighboring gene microRNA 3649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1800052-1800630 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4122 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:1854087-1854680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1875063-1875563 Neighboring gene ribosomal protein S4X pseudogene 14 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:1885224-1885742 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:1885743-1886260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1904713-1905280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1905392-1906297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1906298-1907202 Neighboring gene uncharacterized LOC105369602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1913659-1914581 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5812 Neighboring gene uncharacterized LOC105369601

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids. Ruiz M, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Apr. PMID 33444759
  2. Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations. Kobayashi H, et al. J Atheroscler Thromb, 2019 Apr 1. PMID 30135333, Free PMC Article
  3. Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study. Zhou L, et al. Mol Med Rep, 2017 Oct. PMID 28765899, Free PMC Article
  4. A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population. Yang G, et al. Metab Syndr Relat Disord, 2016 Sep. PMID 27348122
  5. Tumor expression of adiponectin receptor 2 and lethal prostate cancer. Rider JR, et al. Carcinogenesis, 2015 Jun. PMID 25863129, Free PMC Article

See all (161) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
    Title: AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.
  2. Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
    Title: Association of Adiponectin Receptors with Metabolic and Immune Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and Observational Findings.
  3. AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
    Title: AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway.
  4. Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
    Title: Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids.
  5. The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
    Title: The expression and relationship of AdipoR1/R2 in gastric intestinal metaplasia.
  6. Adiponectin is associated with cardio-metabolic traits in Mexican children.
    Title: Adiponectin is associated with cardio-metabolic traits in Mexican children.
  7. Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
    Title: Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins.
  8. The primary cellular function of AdipoR2 is to maintain membrane fluidity in most human cell types and that adiponectin is not required for this function.
    Title: AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin.
  9. Human diabetic kidneys show decreased intraglomerular AdipoR1/AdipoR2 expression.
    Title: The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes.
  10. AdipoR2 single nucleotide polymorphism is associated with increases glomerular filtration rate.
    Title: Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations.
Submit: New GeneRIF Correction See all GeneRIFs (129)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC4640, FLJ21432

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables adipokinetic hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adiponectin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adiponectin-activated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adiponectin-activated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in vascular wound healing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
adiponectin receptor protein 2
Names
progestin and adipoQ receptor family member 2
progestin and adipoQ receptor family member II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001375363.1 → NP_001362292.1  adiponectin receptor protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005183, AC005343
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 396
    HlyIII; Haemolysin-III related

  2. NM_001375364.1 → NP_001362293.1  adiponectin receptor protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005183, AC005343
    Consensus CDS
    CCDS8511.1
    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 363
    HlyIII; Haemolysin-III related

  3. NM_001375365.1 → NP_001362294.1  adiponectin receptor protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005183, AC005343
    Consensus CDS
    CCDS8511.1
    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 363
    HlyIII; Haemolysin-III related

  4. NM_024551.3 → NP_078827.2  adiponectin receptor protein 2 isoform 2

    See identical proteins and their annotated locations for NP_078827.2

    Status: VALIDATED

    Source sequence(s)
    AC005183, AC005343
    Consensus CDS
    CCDS8511.1
    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
    Related
    ENSP00000349616.4, ENST00000357103.5
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 363
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    1691070..1788674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521024.2 → XP_011519326.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011519326.1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 363
    HlyIII; Haemolysin-III related

  2. XM_006719018.3 → XP_006719081.1  adiponectin receptor protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006719081.1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
    Conserved Domains (1) summary
    pfam03006
    Location:140 → 363
    HlyIII; Haemolysin-III related

  3. XM_047429547.1 → XP_047285503.1  adiponectin receptor protein 2 isoform X2

  4. XM_047429548.1 → XP_047285504.1  adiponectin receptor protein 2 isoform X2

  5. XM_047429545.1 → XP_047285501.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  6. XM_047429546.1 → XP_047285502.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654718.1 Reference GRCh38.p14 PATCHES

    Range
    33214..130818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332319.1 → XP_054188294.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  2. XM_054332320.1 → XP_054188295.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  3. XM_054332323.1 → XP_054188298.1  adiponectin receptor protein 2 isoform X2

  4. XM_054332324.1 → XP_054188299.1  adiponectin receptor protein 2 isoform X2

  5. XM_054332321.1 → XP_054188296.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  6. XM_054332322.1 → XP_054188297.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    1687685..1784807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373229.1 → XP_054229204.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  2. XM_054373230.1 → XP_054229205.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  3. XM_054373233.1 → XP_054229208.1  adiponectin receptor protein 2 isoform X2

  4. XM_054373234.1 → XP_054229209.1  adiponectin receptor protein 2 isoform X2

  5. XM_054373231.1 → XP_054229206.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737

  6. XM_054373232.1 → XP_054229207.1  adiponectin receptor protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q53YY5, Q86V24, Q9H737
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86V24.1 GenPept UniProtKB/Swiss-Prot:Q86V24

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