ghsra growth hormone secretagogue receptor a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ghsraprovided by ZNC
Official Full Name: growth hormone secretagogue receptor aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-238
See related: Ensembl:ENSDARG00000056230 AllianceGenome:ZFIN:ZDB-GENE-070912-238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-244m8.1
Summary: Predicted to enable growth hormone secretagogue receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within signal transduction. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including brain; brainstem and spinal white matter; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in obesity. Orthologous to human GHSR (growth hormone secretagogue receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (25551457..25553607, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (25895823..25897973, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.
Title: CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism.
Fish paralogues of the human ghrelin and motilin receptor genes were identified, including those from the zebrafish.[ghrelin receptor; motilin receptor]
Title: Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables growth hormone secretagogue receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: growth hormone secretagogue receptor a

Names: GHS-R1a; GHSR2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146272.1 → NP_001139744.1 growth hormone secretagogue receptor a

Status: PROVISIONAL

Source sequence(s)

CR848726

UniProtKB/TrEMBL

A0A8M1NQI5, B0V1I9

Related

ENSDARP00000073156.4, ENSDART00000078695.5

Conserved Domains (2) summary

pfam00001
Location:54 → 317

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:49 → 333

7tm_4; Olfactory receptor