cacnb2a calcium channel, voltage-dependent, beta 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cacnb2aprovided by ZNC
Official Full Name: calcium channel, voltage-dependent, beta 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080808-7
See related: Ensembl:ENSDARG00000099045 AllianceGenome:ZFIN:ZDB-GENE-080808-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cacnb2b; CACNB2.1
Summary: Predicted to enable high voltage-gated calcium channel activity. Acts upstream of or within embryonic heart tube morphogenesis; glial cell development; and retina development in camera-type eye. Predicted to be located in sarcolemma. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (71792828..71837256, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (71590612..71637855, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta2.1 subunit may function in the heart as a a membrane associated guanylate kinase scaffolding unit to maintain N-cadherin-based adherens junctions and heart tube integrity
Title: Voltage-gated calcium channel CACNB2 (β2.1) protein is required in the heart for control of cell proliferation and heart tube integrity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit beta-2a

Names: CAB2b.1; calcium channel beta subunit 2.1; voltage-dependent calcium channel beta 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083568.2 → NP_001077037.2 voltage-dependent L-type calcium channel subunit beta-2a isoform 1

Status: VALIDATED

Source sequence(s)

CU607104

Related

ENSDARP00000139872.1, ENSDART00000160449.2
NM_001423819.1 → NP_001410748.1 voltage-dependent L-type calcium channel subunit beta-2a isoform 2

Status: VALIDATED

Source sequence(s)

CU607104

Related

ENSDARP00000135383.1, ENSDART00000168645.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

71792828..71837256 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068222417.1 → XP_068078518.1 voltage-dependent L-type calcium channel subunit beta-2a isoform X2

Related

ENSDARP00000141789.1, ENSDART00000160512.2
XM_068222418.1 → XP_068078519.1 voltage-dependent L-type calcium channel subunit beta-2a isoform X3
XM_068222416.1 → XP_068078517.1 voltage-dependent L-type calcium channel subunit beta-2a isoform X1

Related

ENSDARP00000133097.1, ENSDART00000168754.2