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lss lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) [ Danio rerio (zebrafish) ]

Gene ID: 795400, updated on 2-Nov-2024

Summary

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Official Symbol
lssprovided by ZNC
Official Full Name
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050119-7
See related
Ensembl:ENSDARG00000061274 AllianceGenome:ZFIN:ZDB-GENE-050119-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable lanosterol synthase activity. Acts upstream of or within cholesterol biosynthetic process and regulation of chondrocyte differentiation. Predicted to be active in lipid droplet. Is expressed in several structures, including heart; integument; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in alopecia-mental retardation syndrome 4; cataract; cataract 44; and hypotrichosis 14. Orthologous to human LSS (lanosterol synthase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See lss in Genome Data Viewer
Location:
chromosome: 9
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (38481857..38500391)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (38672062..38690596)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily A, polypeptide 1, gene 4 Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene leishmanolysin-like (metallopeptidase M8 family) Neighboring gene oxysterol binding protein-like 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish ETV7 regulates red blood cell development through the cholesterol synthesis pathway. Quintana AM, et al. Dis Model Mech, 2014 Feb. PMID 24357328, Free PMC Article
  2. Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior. Porseryd T, et al. Front Behav Neurosci, 2017. PMID 28473760, Free PMC Article
  3. Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury. Gourain V, et al. Front Neurosci, 2021. PMID 34054419, Free PMC Article
  4. Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure. Hermsen SA, et al. Toxicol Sci, 2012 May. PMID 22382673
  5. AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model. Deng R, et al. Acta Neuropathol, 2023 Aug. PMID 37119330, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC163068

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables intramolecular transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables lanosterol synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within triterpenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lanosterol synthase
NP_001077036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083567.1 → NP_001077036.1  lanosterol synthase

    See identical proteins and their annotated locations for NP_001077036.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134214
    UniProtKB/TrEMBL
    A4FVM4
    Related
    ENSDARP00000081675.4, ENSDART00000087241.6
    Conserved Domains (2) summary
    cd02892
    Location:78 → 720
    SQCY_1; Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization ...
    TIGR01787
    Location:77 → 722
    squalene_cyclas; squalene/oxidosqualene cyclases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    38481857..38500391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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