ciao1 cytosolic iron-sulfur assembly component 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ciao1provided by ZNC
Official Full Name: cytosolic iron-sulfur assembly component 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-839
See related: Ensembl:ENSDARG00000059212 AllianceGenome:ZFIN:ZDB-GENE-040426-839
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr39; zgc:55911; zgc:77394
Summary: Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (4779744..4788985, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (4723477..4732718, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.
Title: CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation by iron-sulfur cluster transfer	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IEA Inferred from Electronic Annotation more info
part_of cytosolic [4Fe-4S] assembly targeting complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: probable cytosolic iron-sulfur protein assembly protein ciao1

Names: WD repeat domain 39; cytosolic iron-sulfur protein assembly 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200147.2 → NP_956441.2 probable cytosolic iron-sulfur protein assembly protein ciao1

See identical proteins and their annotated locations for NP_956441.2

Status: PROVISIONAL

Source sequence(s)

BC065658

UniProtKB/Swiss-Prot

B0S611, Q6P0D9, Q803C8

Related

ENSDARP00000076693.3, ENSDART00000082256.4

Conserved Domains (3) summary

COG2319
Location:22 → 329

WD40; WD40 repeat [General function prediction only]

cd00200
Location:22 → 326

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:19 → 59

7WD40; WD40 repeat [structural motif]