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ckmb creatine kinase, muscle b [ Danio rerio (zebrafish) ]

Gene ID: 794752, updated on 18-Sep-2024

Summary

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Official Symbol
ckmbprovided by ZNC
Official Full Name
creatine kinase, muscle bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2128
See related
Ensembl:ENSDARG00000040565 AllianceGenome:ZFIN:ZDB-GENE-040426-2128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ckm3; zgc:64204; zgc:92070; wu:fb55e09
Summary
Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in extracellular space. Is expressed in adaxial cell; head; heart; musculature system; and pectoral fin. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See ckmb in Genome Data Viewer
Location:
chromosome: 15
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23643718..23646968, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23708453..23711808, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-182i3.11 Neighboring gene MAP/microtubule affinity-regulating kinase 4b Neighboring gene kinesin light chain 3 Neighboring gene excision repair cross-complementation group 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Myomesin is part of an integrity pathway that responds to sarcomere damage and disease. Prill K, et al. PLoS One, 2019. PMID 31644553, Free PMC Article
  2. Comprehensive transcriptome analysis reveal key molecular events in the pearl oyster after pre-grafting conditioning. Jiao Y, et al. Fish Shellfish Immunol, 2019 Sep. PMID 31195116
  3. Protein expression patterns in zebrafish skeletal muscle: initial characterization and the effects of hypoxic exposure. Bosworth CA 4th, et al. Proteomics, 2005 Apr. PMID 15732137
  4. Transcriptome analysis of the response to chronic constant hypoxia in zebrafish hearts. Marques IJ, et al. J Comp Physiol B, 2008 Jan. PMID 17828398, Free PMC Article
  5. The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish. Doganli C, et al. J Cell Sci, 2012 Dec 15. PMID 23097043

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC64204, MGC92070

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables creatine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphocreatine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
creatine kinase, muscle b
NP_001099153.1
XP_005157650.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105683.1 → NP_001099153.1  creatine kinase, muscle b

    See identical proteins and their annotated locations for NP_001099153.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153631
    UniProtKB/TrEMBL
    A8E5L0
    Related
    ENSDARP00000130760.2, ENSDART00000168845.2
    Conserved Domains (1) summary
    cd00716
    Location:16 → 372
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    23643718..23646968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157593.2 → XP_005157650.1  creatine kinase, muscle b isoform X1

    See identical proteins and their annotated locations for XP_005157650.1

    UniProtKB/TrEMBL
    A0A0R4IA56, A0A8N7XJ25, F6P1F4, Q7T306
    Related
    ENSDARP00000059365.5, ENSDART00000059366.7
    Conserved Domains (1) summary
    cd00716
    Location:16 → 372
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
Nucleotide Protein Strain
Heading Accession and Version

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