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dync2i2 dynein 2 intermediate chain 2 [ Danio rerio (zebrafish) ]

Gene ID: 794361, updated on 2-Nov-2024

Summary

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Official Symbol
dync2i2provided by ZNC
Official Full Name
dynein 2 intermediate chain 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070928-9
See related
Ensembl:ENSDARG00000057635 AllianceGenome:ZFIN:ZDB-GENE-070928-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wdr34; dync2i1; zgc:171284
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Acts upstream of or within intraciliary transport and neural tube development. Located in cilium. Is expressed in central nervous system; pronephric duct; and retina. Used to study neural tube defect. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dync2i2 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (13217896..13225402, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (13120908..13128414, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene si:dkey-228b2.6 Neighboring gene outer dense fiber of sperm tails 2a Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene uncharacterized LOC137488787 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like b Neighboring gene SET nuclear proto-oncogene b Neighboring gene adenosine A2a receptor b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. Yin H, et al. J Hum Genet, 2020 Nov. PMID 32576942, Free PMC Article
  2. Retrograde intraflagellar transport by cytoplasmic dynein-2 is required for outer segment extension in vertebrate photoreceptors but not arrestin translocation. Krock BL, et al. Invest Ophthalmol Vis Sci, 2009 Nov. PMID 19474410, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways.
    Title: WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC171284

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intraciliary transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ciliary plasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic dynein 2 intermediate chain 2
Names
WD repeat domain 34
dynein, cytoplasmic 2, intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105690.1 → NP_001099160.1  cytoplasmic dynein 2 intermediate chain 2

    See identical proteins and their annotated locations for NP_001099160.1

    Status: PROVISIONAL

    Source sequence(s)
    BC152526
    UniProtKB/TrEMBL
    A0A8M1NFY2, A7MD87
    Related
    ENSDARP00000074797.4, ENSDART00000080347.6
    Conserved Domains (2) summary
    COG2319
    Location:66 → 481
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:187 → 229
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    13217896..13225402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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