U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Stmn4 stathmin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79423, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Stmn4provided by RGD
Official Full Name
stathmin 4provided by RGD
Primary source
RGD:69349
See related
EnsemblRapid:ENSRNOG00000053334 AllianceGenome:RGD:69349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rb3; Lagl
Summary
Predicted to enable tubulin binding activity. Predicted to be involved in microtubule depolymerization; neuron projection development; and regulation of microtubule polymerization or depolymerization. Predicted to be located in Golgi apparatus and growth cone. Predicted to be active in cytoplasm and neuron projection. Orthologous to human STMN4 (stathmin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 200.2) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Stmn4 in Genome Data Viewer
Location:
15p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44716825..44734776)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40541305..40559253)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (43007901..43025852)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene microRNA 6320 Neighboring gene tripartite motif-containing 35 Neighboring gene adrenoceptor alpha 1A Neighboring gene dihydropyrimidinase-like 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy. Nakazawa T, et al. Brain Res, 2005 Nov 9. PMID 16256088
  2. Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain. Nakao C, et al. J Biol Chem, 2004 May 28. PMID 15039434
  3. The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system. Ozon S, et al. Eur J Biochem, 1997 Sep 15. PMID 9342231
  4. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon S, et al. J Neurosci Res, 1999 Jun 1. PMID 10369222
  5. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. Ozon S, et al. J Neurochem, 1998 Jun. PMID 9603203

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. regulatory role of the unique N-terminal domain of RB3 in microtubule dynamics would contribute to the physiological regulation of neuronal morphogenesis
    Title: Modulation of the stathmin-like microtubule destabilizing activity of RB3, a neuron-specific member of the SCG10 family, by its N-terminal domain.
  2. RB3 is the unique response protein in the stathmin-related proteins following optic nerve axotomy and the induced RB3 may play a critical role in the CNTF-induced response on the axotomized retinal ganglion cells
    Title: Selective upregulation of RB3/stathmin4 by ciliary neurotrophic factor following optic nerve axotomy.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109417

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
stathmin-4
Names
stathmin-like 4
stathmin-like protein B3
stathmin-like-protein RB3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270855.1 → NP_001257784.1  stathmin-4 isoform b

    See identical proteins and their annotated locations for NP_001257784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the 3' end compared to variant 1. This exon has an in-frame stop codon, resulting in an isoform (b) with a shorter and distinct C-terminus compared to isoform a. Variants 2 and 6 both encode the same isoform (b).
    Source sequence(s)
    BC092646, JAXUCZ010000015
    UniProtKB/TrEMBL
    Q568Y8
    Conserved Domains (1) summary
    pfam00836
    Location:76 → 203
    Stathmin; Stathmin family

  2. NM_001270856.1 → NP_001257785.1  stathmin-4 isoform c

    See identical proteins and their annotated locations for NP_001257785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC092646, JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    A6K6M7, A6K6M9
    Conserved Domains (1) summary
    pfam00836
    Location:49 → 184
    Stathmin; Stathmin family

  3. NM_001270857.1 → NP_001257786.1  stathmin-4 isoform d

    See identical proteins and their annotated locations for NP_001257786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of the next exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC092646, JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K6M7
    Related
    ENSRNOP00000069450.2, ENSRNOT00000087709.3
    Conserved Domains (1) summary
    pfam00836
    Location:48 → 183
    Stathmin; Stathmin family

  4. NM_001270858.1 → NP_001257787.1  stathmin-4 isoform e

    See identical proteins and their annotated locations for NP_001257787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and has an alternate exon in the 3' end compared to variant 1. This additional exon has an in-frame stop codon, resulting in an isoform (e) with a shorter and distinct C-terminus and lacking an alternate internal segment compared to isoform a.
    Source sequence(s)
    BC092646, JAXUCZ010000015
    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    Q568Y8
    Related
    ENSRNOP00000108777.1, ENSRNOT00000158569.1
    Conserved Domains (1) summary
    pfam00836
    Location:49 → 176
    Stathmin; Stathmin family

  5. NM_001270859.1 → NP_001257788.1  stathmin-4 isoform b

    See identical proteins and their annotated locations for NP_001257788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has an alternate exon in the 3' end compared to variant 1. This exon has an in-frame stop codon, resulting in an isoform (b) with a shorter and distinct C-terminus compared to isoform a. Variants 2 and 6 both encode the same isoform (b).
    Source sequence(s)
    BC092646, CB580507
    UniProtKB/TrEMBL
    Q568Y8
    Related
    ENSRNOP00000072524.1, ENSRNOT00000084753.3
    Conserved Domains (1) summary
    pfam00836
    Location:76 → 203
    Stathmin; Stathmin family

  6. NM_019176.2 → NP_062049.1  stathmin-4 isoform a

    See identical proteins and their annotated locations for NP_062049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC092646, JAXUCZ010000015
    UniProtKB/TrEMBL
    A6K6M6, A6K6M7
    Conserved Domains (1) summary
    pfam00836
    Location:76 → 211
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    44716825..44734776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770778.3 → XP_008769000.1  stathmin-4 isoform X2

    UniProtKB/TrEMBL
    A6K6M7
    Conserved Domains (1) summary
    pfam00836
    Location:75 → 210
    Stathmin; Stathmin family

  2. XM_063274689.1 → XP_063130759.1  stathmin-4 isoform X5

  3. XM_063274678.1 → XP_063130748.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    A6K6M6

  4. XM_039093677.2 → XP_038949605.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    A6K6M6, A6K6M7
    Conserved Domains (1) summary
    pfam00836
    Location:76 → 211
    Stathmin; Stathmin family

  5. XM_063274681.1 → XP_063130751.1  stathmin-4 isoform X2

  6. XM_063274687.1 → XP_063130757.1  stathmin-4 isoform X4

  7. XM_063274686.1 → XP_063130756.1  stathmin-4 isoform X4

  8. XM_063274683.1 → XP_063130753.1  stathmin-4 isoform X3

    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    A6K6M9

  9. XM_063274682.1 → XP_063130752.1  stathmin-4 isoform X3

    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    A6K6M9

  10. XM_039093679.1 → XP_038949607.1  stathmin-4 isoform X4

    UniProtKB/TrEMBL
    A6K6M7
    Conserved Domains (1) summary
    pfam00836
    Location:48 → 183
    Stathmin; Stathmin family

  11. XM_063274684.1 → XP_063130754.1  stathmin-4 isoform X3

    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    A6K6M9

  12. XM_063274679.1 → XP_063130749.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    A6K6M6

  13. XM_063274680.1 → XP_063130750.1  stathmin-4 isoform X1

    UniProtKB/TrEMBL
    A6K6M6
    Related
    ENSRNOP00000073294.1, ENSRNOT00000091567.3

  14. XM_063274685.1 → XP_063130755.1  stathmin-4 isoform X3

    UniProtKB/Swiss-Prot
    P63043
    UniProtKB/TrEMBL
    A6K6M9

  15. XM_063274688.1 → XP_063130758.1  stathmin-4 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63043.1 GenPept UniProtKB/Swiss-Prot:P63043

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools