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rasal2 RAS protein activator like 2 [ Danio rerio (zebrafish) ]

Gene ID: 793730, updated on 19-Jun-2024

Summary

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Official Symbol
rasal2provided by ZNC
Official Full Name
RAS protein activator like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-180
See related
Ensembl:ENSDARG00000036257 AllianceGenome:ZFIN:ZDB-GENE-070912-180
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc75a03; wu:fc75a03; si:ch211-198i20.2
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within regulation of GTPase activity and signal transduction. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rasal2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (35732829..35851661)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (35750412..35869204)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Tctex1 domain containing 4 Neighboring gene ankyrin repeat domain 45 Neighboring gene DEAH (Asp-Glu-Ala-His) box helicase 9 Neighboring gene laminin, gamma 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein nGAP

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    35732829..35851661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001332652.8 → XP_001332688.5  ras GTPase-activating protein nGAP isoform X3

    UniProtKB/TrEMBL
    A0A8M1Q157, F1QX32
    Related
    ENSDARP00000052665.6, ENSDART00000052666.7
    Conserved Domains (6) summary
    cd04013
    Location:330 → 469
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:460 → 790
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:453 → 788
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:780 → 1304
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1176 → 1314
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:204 → 388
    PH-like; Pleckstrin homology-like domain

  2. XM_005171321.4 → XP_005171378.1  ras GTPase-activating protein nGAP isoform X1

    UniProtKB/TrEMBL
    A0A8M2BIR4
    Conserved Domains (6) summary
    cd04013
    Location:419 → 558
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:549 → 879
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:542 → 877
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:869 → 1393
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1265 → 1403
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:293 → 477
    PH-like; Pleckstrin homology-like domain

  3. XM_005171322.4 → XP_005171379.1  ras GTPase-activating protein nGAP isoform X2

    UniProtKB/TrEMBL
    A0A8M2BIM6
    Conserved Domains (6) summary
    cd04013
    Location:419 → 558
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:549 → 872
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:542 → 870
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:862 → 1386
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1258 → 1396
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:293 → 477
    PH-like; Pleckstrin homology-like domain

  4. XM_005171325.4 → XP_005171382.1  ras GTPase-activating protein nGAP isoform X5

    UniProtKB/TrEMBL
    A0A8M2BIN1
    Conserved Domains (6) summary
    cd04013
    Location:161 → 300
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:291 → 621
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:284 → 619
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:611 → 1135
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1007 → 1145
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:35 → 219
    PH-like; Pleckstrin homology-like domain

  5. XM_005171324.4 → XP_005171381.1  ras GTPase-activating protein nGAP isoform X4

    UniProtKB/TrEMBL
    A0A8M2BJ40
    Conserved Domains (6) summary
    cd04013
    Location:164 → 303
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:294 → 624
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:287 → 622
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:614 → 1138
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1010 → 1148
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:38 → 222
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
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