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tgm1l3 transglutaminase 1 like 3 [ Danio rerio (zebrafish) ]

Gene ID: 793448, updated on 2-Nov-2024

Summary

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Official Symbol
tgm1l3provided by ZNC
Official Full Name
transglutaminase 1 like 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-120718-1
See related
AllianceGenome:ZFIN:ZDB-GENE-120718-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable metal ion binding activity and protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within keratinization and peptide cross-linking. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See tgm1l3 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (40234646..40276231, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (40277504..40297530)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene transglutaminase 1 like 2 Neighboring gene transglutaminase 1-like 6 Neighboring gene terminal nucleotidyltransferase 5Ab Neighboring gene ELOVL fatty acid elongase 4b Neighboring gene uncharacterized LOC137489148 Neighboring gene MTCL family member 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the transglutaminase gene family in zebrafish and in vivo analysis of transglutaminase-dependent bone mineralization. Deasey S, et al. Amino Acids, 2012 Feb. PMID 21809079, Free PMC Article
  2. Generation of a double binary transgenic zebrafish model to study myeloid gene regulation in response to oncogene activation in melanocytes. Kenyon A, et al. Dis Model Mech, 2018 Apr 6. PMID 29666124, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within keratinization IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptide cross-linking IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase K
Names
TG1-48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    40234646..40276231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001331878.8 → XP_001331914.1  protein-glutamine gamma-glutamyltransferase K

    UniProtKB/TrEMBL
    A0A8M1Q6T7
    Conserved Domains (5) summary
    smart00460
    Location:429 → 520
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:428 → 565
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:166 → 283
    Transglut_N; Transglutaminase family
    pfam00927
    Location:761 → 846
    Transglut_C; Transglutaminase family, C-terminal ig like domain
    pfam02389
    Location:42 → 128
    Cornifin; Cornifin (SPRR) family
Nucleotide Protein Strain
Heading Accession and Version

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