U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tia1 TIA1 cytotoxic granule-associated RNA binding protein [ Danio rerio (zebrafish) ]

Gene ID: 793165, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
tia1provided by ZNC
Official Full Name
TIA1 cytotoxic granule-associated RNA binding proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1506
See related
Ensembl:ENSDARG00000052536 AllianceGenome:ZFIN:ZDB-GENE-030131-1506
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb73d10; zgc:55520; wu:fb73d10; wu:fc02b04
Summary
Enables mRNA 3'-UTR binding activity. Is expressed in brain; retina; retinal ganglion cell layer; retinal inner nuclear layer; and trunk. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See tia1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (56950861..56964509, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (56280644..56294330, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1Db Neighboring gene si:ch211-127d4.3 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene transmembrane protein 232

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Proteomic analysis of cellular protein expression profiles in response to grass carp reovirus infection. Xu D, et al. Fish Shellfish Immunol, 2015 Jun. PMID 25783000
  2. Amyloid-like Self-Assembly of a Cellular Compartment. Boke E, et al. Cell, 2016 Jul 28. PMID 27471966, Free PMC Article
  3. The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior. Shankar P, et al. Toxicol Sci, 2022 May 26. PMID 35377459, Free PMC Article
  4. ALS-associated genes display CNS expression in the developing zebrafish. Laboissonniere LA, et al. Gene Expr Patterns, 2018 Dec. PMID 30165106
  5. Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Vejnar CE, et al. Genome Res, 2019 Jul. PMID 31227602, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC55520

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
cytotoxic granule associated RNA binding protein TIA1
Names
cytotoxic granule-associated RNA binding protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212628.1 → NP_997793.1  cytotoxic granule associated RNA binding protein TIA1

    See identical proteins and their annotated locations for NP_997793.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045368
    UniProtKB/TrEMBL
    A0A8N7V096, A2ATY3, Q7ZVY0
    Related
    ENSDARP00000068889.4, ENSDART00000074400.5
    Conserved Domains (4) summary
    cd12615
    Location:9 → 82
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:95 → 174
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:204 → 277
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6 → 270
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    56950861..56964509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301867.3 → XP_009300142.1  cytotoxic granule associated RNA binding protein TIA1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AZZ3
    Conserved Domains (4) summary
    cd12615
    Location:9 → 82
    RRM1_TIA1; RNA recognition motif 1 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12618
    Location:95 → 174
    RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    cd12621
    Location:204 → 277
    RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
    TIGR01661
    Location:6 → 270
    ELAV_HUD_SF; ELAV/HuD family splicing factor

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394615.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    305757..310746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395246.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    201190..206179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395376.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    220084..232691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools