rgs9b regulator of G protein signaling 9b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs9bprovided by ZNC
Official Full Name: regulator of G protein signaling 9bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1708
See related: Ensembl:ENSDARG00000045156 AllianceGenome:ZFIN:ZDB-GENE-040426-1708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rgs9; zC147H1.2; zgc:73189
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; regulation of signal transduction; and visual perception. Predicted to be active in cytoplasm; neuron projection; and plasma membrane. Is expressed in eye and telencephalon. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (18681423..18717659)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (18559493..18595785)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regulator of G-protein signaling 9b

Names: regulator of G-protein signalling 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200830.2 → NP_957124.2 regulator of G-protein signaling 9b

Status: PROVISIONAL

Source sequence(s)

AL772266

UniProtKB/TrEMBL

A0A8M1PFV7, Q6ZM84

Related

ENSDARP00000119059.1, ENSDART00000143979.2

Conserved Domains (3) summary

smart00224
Location:223 → 283

GGL; G protein gamma subunit-like motifs

cd08739
Location:295 → 415

RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein

cd04450
Location:26 → 112

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

18681423..18717659

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480167.2 → XP_021335842.1 regulator of G-protein signaling 9b isoform X1

UniProtKB/TrEMBL

A0A8M9PWJ6

Conserved Domains (4) summary

smart00224
Location:223 → 283

GGL; G protein gamma subunit-like motifs

cd08739
Location:295 → 415

RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein

cd04450
Location:26 → 112

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

cl27341
Location:118 → 169

Ribonuc_red_lgC; Ribonucleotide reductase, barrel domain