tpbg trophoblast glycoprotein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tpbgprovided by ZNC
Official Full Name: trophoblast glycoproteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-091218-2
See related: Ensembl:ENSDARG00000037186 AllianceGenome:ZFIN:ZDB-GENE-091218-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tpbgb; sc:d0323; sc:d0347
Summary: Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including head mesenchyme; median fin fold; nervous system; notochord; and otic vesicle. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (4834527..4836218, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (5005238..5006929, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trophoblast glycoprotein

Names: 5T4 oncofetal trophoblast glycoprotein; Wnt-activated inhibitory factor 1c; trophoblast glycoprotein b; waif1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252462.1 → NP_001239391.1 trophoblast glycoprotein precursor

See identical proteins and their annotated locations for NP_001239391.1

Status: PROVISIONAL

Source sequence(s)

JN653075

UniProtKB/TrEMBL

F1Q983, G8HXD5

Related

ENSDARP00000054076.5, ENSDART00000054077.6

Conserved Domains (5) summary

smart00013
Location:41 → 70

LRRNT; Leucine rich repeat N-terminal domain

smart00082
Location:252 → 302

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:76 → 230

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:49 → 68

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:68 → 128

LRR_8; Leucine rich repeat