Hpgd 15-hydroxyprostaglandin dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpgdprovided by RGD
Official Full Name: 15-hydroxyprostaglandin dehydrogenaseprovided by RGD
Primary source: RGD:620087
See related: EnsemblRapid:ENSRNOG00000010610 AllianceGenome:RGD:620087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 301.9), Kidney (RPKM 262.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (38996876..39034831, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (33986265..34024228, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (37457134..37495758, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results showed that 15-PGDH mRNA and protein expression was reduced in the hypothalamus and lungs in stressed animals compared with controls, which was correlated with a reduction of enzymatic activity
Title: Chronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats.
results support a possibility that 15-PGDH may regulate postnatal kidney development through interaction with COX-2
Title: Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney.
NS398, a COX-2 specific inhibitor, protects neurons against thrombin toxicity, by inducing active PGDH. These data implicate PGDH in thrombin-mediated neuronal cell death.
Title: Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:498472 (e-PCR)
- UniSTS:498472

Hpgd (e-PCR), detects polymorphism
- UniSTS:498472

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables NAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in parturition	ISO Inferred from Sequence Orthology more info
involved_in parturition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of prostaglandin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of prostaglandin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in thrombin-activated receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Names: 15-PGDH; NAD-dependent 15-hydroxyprostaglandin dehydrogenase; PGDH; eicosanoid/docosanoid dehydrogenase; hydroxyprostaglandin dehydrogenase 15 (NAD); prostaglandin dehydrogenase 1

NP_077366.2

EC 1.1.1.141

EC 1.1.1.232

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024390.3 → NP_077366.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

See identical proteins and their annotated locations for NP_077366.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

O08699, Q6P687

UniProtKB/TrEMBL

A6KIY1

Related

ENSRNOP00000014229.4, ENSRNOT00000014229.6

Conserved Domains (1) summary

cd05323
Location:6 → 254

ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs