snai1b snail family zinc finger 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: snai1bprovided by ZNC
Official Full Name: snail family zinc finger 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-514
See related: Ensembl:ENSDARG00000046019 AllianceGenome:ZFIN:ZDB-GENE-980526-514
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sna2; snail2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac muscle progenitor cell migration to the midline involved in heart field formation; mesodermal cell migration; and posterior lateral line neuromast primordium migration. Is expressed in several structures, including ectoderm; heart; mesoderm; neural crest; and trunk. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (2502228..2513415, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (2567181..2573868, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
Title: The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.
Title: Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.
The results provide the molecular mechanism how snai1b controls the morphogenesis of heart during embryonic development
Title: Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos.
Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
Title: Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
Title: Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle progenitor cell migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: snail family zinc finger 1b

Names: snail homolog 1b; snail-2; snail1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130989.3 → NP_571064.2 snail family zinc finger 1b

See identical proteins and their annotated locations for NP_571064.2

Status: PROVISIONAL

Source sequence(s)

BC162632

UniProtKB/TrEMBL

A0A8M9PT75, B3DH44

Related

ENSDARP00000067651.1, ENSDART00000067652.4

Conserved Domains (3) summary

sd00017
Location:175 → 195

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:201 → 223

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:188 → 211

zf-H2C2_2; Zinc-finger double domain