he1.3 hatching enzyme 1, tandem duplicate 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: he1.3provided by ZNC
Official Full Name: hatching enzyme 1, tandem duplicate 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040518-1
See related: Ensembl:ENSDARG00000022670 AllianceGenome:ZFIN:ZDB-GENE-040518-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: h-2; he2; hce2; wu:fb77c08; si:ch211-246m6.9
Summary: Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in hatching gland cell. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (14102386..14104673)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (14077609..14079896)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hatching enzyme 1, tandem duplicate 3

Names: hatching enzyme 2; high choriolytic enzyme

NP_001091658.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098188.1 → NP_001091658.1 hatching enzyme 1, tandem duplicate 3 precursor

See identical proteins and their annotated locations for NP_001091658.1

Status: PROVISIONAL

Source sequence(s)

BC139601

UniProtKB/TrEMBL

A4VCG4

Related

ENSDARP00000118735.1, ENSDART00000146397.3

Conserved Domains (2) summary

pfam01400
Location:86 → 264

Astacin; Astacin (Peptidase family M12A)

cl00064
Location:82 → 263

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...