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Galnt1 polypeptide N-acetylgalactosaminyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79214, updated on 2-Nov-2024

Summary

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Official Symbol
Galnt1provided by RGD
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 1provided by RGD
Primary source
RGD:620358
See related
EnsemblRapid:ENSRNOG00000016207 AllianceGenome:RGD:620358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Orthologous to human GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 233.4), Spleen (RPKM 209.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Galnt1 in Genome Data Viewer
Location:
18p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (15763697..15843598)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (15489015..15568849)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (16141062..16187271)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 24 Neighboring gene INO80 complex subunit C Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L29 like 2 Neighboring gene microRNA 187

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the GalNAc-T1 lectin domain plays a critical role in enzymatic activity, and GalNAc-T1 has two activities distinguished by their sensitivities to inhibition with free GalNAc
    Title: The lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1 is involved in O-glycosylation of a polypeptide with multiple acceptor sites.
  2. the lectin domain of GalNAc-T1 has at least two functional repeats, allowing the possibility of multivalent interactions with GalNAc residues on the acceptor polypeptide during glycosylation
    Title: Function of the lectin domain of polypeptide N-acetylgalactosaminyltransferase 1.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 1
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
galNAc-T1
polypeptide GalNAc transferase 1
polypeptide GalNAc transferase T1
pp-GaNTase 1
protein-UDP acetylgalactosaminyltransferase 1
NP_077349.1
XP_038953064.1
XP_038953065.1
XP_063133670.1
XP_063133671.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024373.2 → NP_077349.1  polypeptide N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_077349.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q10473
    UniProtKB/TrEMBL
    A0A8I5ZUR3, A6J2K1
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    15763697..15843598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097137.2 → XP_038953065.1  polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10473
    UniProtKB/TrEMBL
    A0A8I5ZUR3, A6J2K1
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_039097136.2 → XP_038953064.1  polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10473
    UniProtKB/TrEMBL
    A0A8I5ZUR3, A6J2K1
    Related
    ENSRNOP00000022117.2, ENSRNOT00000022117.6
    Conserved Domains (2) summary
    cd02510
    Location:119 → 419
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:432 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. XM_063277601.1 → XP_063133671.1  polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10473
    UniProtKB/TrEMBL
    A6J2K1

  4. XM_063277600.1 → XP_063133670.1  polypeptide N-acetylgalactosaminyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q10473
    UniProtKB/TrEMBL
    A6J2K1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10473.1 GenPept UniProtKB/Swiss-Prot:Q10473

Gene LinkOut

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