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rnaset2 ribonuclease T2 [ Danio rerio (zebrafish) ]

Gene ID: 791890, updated on 2-Nov-2024

Summary

Official Symbol
rnaset2provided by ZNC
Official Full Name
ribonuclease T2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2513
See related
Ensembl:ENSDARG00000036282 AllianceGenome:ZFIN:ZDB-GENE-030131-2513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dre2; fc10c06; wu:fc10c06; zgc:113369
Summary
Predicted to enable RNA endonuclease activity. Acts upstream of or within rRNA catabolic process. Predicted to be located in endoplasmic reticulum lumen and lysosomal lumen. Predicted to be active in extracellular region. Is expressed in several structures, including blastomere; digestive system; gonad; immature eye; and yolk. Used to study RNASET2-deficient cystic leukoencephalopathy. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See rnaset2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (7049210..7064063)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (9737738..9750338)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene CUB and Sushi multiple domains 1a Neighboring gene myomesin 2b Neighboring gene uncharacterized LOC137487361 Neighboring gene uncharacterized LOC137487362 Neighboring gene ribosomal protein S6 kinase, polypeptide 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Clone Names

  • MGC113369, MGC193015

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease T2
Names
RNase Dre2
NP_001025235.2
NP_001307320.1
XP_021336347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030064.2NP_001025235.2  ribonuclease T2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX255965
    UniProtKB/Swiss-Prot
    B8XY56, Q4V9G5
    UniProtKB/TrEMBL
    A0A8M9PY62
    Related
    ENSDARP00000141181.1, ENSDART00000168608.2
    Conserved Domains (1) summary
    pfam00445
    Location:31195
    Ribonuclease_T2; Ribonuclease T2 family
  2. NM_001320391.1NP_001307320.1  ribonuclease T2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX255965, EB859385, EB930108
    UniProtKB/Swiss-Prot
    B8XY56, Q4V9G5
    UniProtKB/TrEMBL
    A0A8M9PY62
    Related
    ENSDARP00000111898.1, ENSDART00000128675.3
    Conserved Domains (1) summary
    pfam00445
    Location:31195
    Ribonuclease_T2; Ribonuclease T2 family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    7049210..7064063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021480672.2XP_021336347.1  ribonuclease T2 isoform X1

    UniProtKB/Swiss-Prot
    B8XY56, Q4V9G5
    UniProtKB/TrEMBL
    A0A8M9PY62
    Related
    ENSDARP00000144562.1, ENSDART00000178997.2
    Conserved Domains (1) summary
    pfam00445
    Location:31195
    Ribonuclease_T2; Ribonuclease T2 family