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FBXL15 F-box and leucine rich repeat protein 15 [ Homo sapiens (human) ]

Gene ID: 79176, updated on 5-Mar-2024

Summary

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Official Symbol
FBXL15provided by HGNC
Official Full Name
F-box and leucine rich repeat protein 15provided by HGNC
Primary source
HGNC:HGNC:28155
See related
Ensembl:ENSG00000107872 MIM:610287; AllianceGenome:HGNC:28155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JET; PSD; Fbl15; FBXO37
Summary
Involved in G2/M transition of mitotic cell cycle; cellular protein metabolic process; and positive regulation of BMP signaling pathway. Located in cytoplasm. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 4.8), colon (RPKM 3.6) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (102420836..102423136)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (103304934..103308100)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104180593..104182893)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3929 Neighboring gene Sharpr-MPRA regulatory region 13585 Neighboring gene nuclear factor kappa B subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104160632-104161328 Neighboring gene Sharpr-MPRA regulatory region 3575 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104169870-104170552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104170553-104171234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3934 Neighboring gene CUE domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104192697-104193332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:104193333-104193966 Neighboring gene microRNA 146b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A cell based screening approach for identifying protein degradation regulators. Simanski S, et al. Cell Cycle, 2017 May 19. PMID 28296622, Free PMC Article
  2. Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2. Choi J, et al. Nat Cell Biol, 2018 May. PMID 29695787, Free PMC Article
  3. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Busino L, et al. Science, 2007 May 11. PMID 17463251
  4. FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells. Saffie R, et al. Cancer Res, 2020 Jun 15. PMID 32350066, Free PMC Article
  5. The ULK1-FBXW5-SEC23B nexus controls autophagy. Jeong YT, et al. Elife, 2018 Dec 31. PMID 30596474, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16137, MGC11279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 15
Names
F-box only protein 37
pleckstrin and Sec7 domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387294.1 → NP_001374223.1  F-box/LRR-repeat protein 15

    Status: VALIDATED

    Source sequence(s)
    AL121928
    Consensus CDS
    CCDS31273.1
    UniProtKB/Swiss-Prot
    A1L4J8, B1AKX8, B1AKX9, B1AKY0, B1AKY1, C9JWA4, Q0D2Q3, Q49AL7, Q5JWA5, Q9H469
    UniProtKB/TrEMBL
    A0A0C4DFV0
    Conserved Domains (3) summary
    cd09293
    Location:139 → 266
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:62 → 88
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:18 → 55
    F-box; F-box domain

  2. NM_024326.4 → NP_077302.3  F-box/LRR-repeat protein 15

    See identical proteins and their annotated locations for NP_077302.3

    Status: VALIDATED

    Source sequence(s)
    AL121928
    Consensus CDS
    CCDS31273.1
    UniProtKB/Swiss-Prot
    A1L4J8, B1AKX8, B1AKX9, B1AKY0, B1AKY1, C9JWA4, Q0D2Q3, Q49AL7, Q5JWA5, Q9H469
    UniProtKB/TrEMBL
    A0A0C4DFV0
    Related
    ENSP00000358972.3, ENST00000369956.8
    Conserved Domains (3) summary
    cd09293
    Location:139 → 266
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:62 → 88
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00646
    Location:18 → 55
    F-box; F-box domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    102420836..102423136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    103304934..103308100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366712.1 → XP_054222687.1  F-box/LRR-repeat protein 15 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H469.2 GenPept UniProtKB/Swiss-Prot:Q9H469

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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