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piga phosphatidylinositol glycan anchor biosynthesis, class A [ Danio rerio (zebrafish) ]

Gene ID: 791759, updated on 28-Oct-2024

Summary

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Official Symbol
pigaprovided by ZNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1086
See related
Ensembl:ENSDARG00000041040 AllianceGenome:ZFIN:ZDB-GENE-040426-1086
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56589; im:6911675
Summary
Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See piga in Genome Data Viewer
Location:
chromosome: 9
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (30374889..30385059, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (30564143..30583162, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 5 Neighboring gene ankyrin repeat and SOCS box containing 11 Neighboring gene si:dkey-18p12.4 Neighboring gene zgc:113314

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Avagyan S, et al. Science, 2021 Nov 5. PMID 34735227
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56589

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit A
NP_001119918.1
XP_005167808.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126446.1 → NP_001119918.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A

    See identical proteins and their annotated locations for NP_001119918.1

    Status: PROVISIONAL

    Source sequence(s)
    BX571845
    UniProtKB/TrEMBL
    A0A8M1NJC4, B0S6Z8
    Related
    ENSDARP00000060133.4, ENSDART00000060134.5
    Conserved Domains (2) summary
    cd03796
    Location:38 → 437
    GT1_PIG-A_like; This family is most closely related to the GT1 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate ...
    COG0438
    Location:39 → 409
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    30374889..30385059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167751.5 → XP_005167808.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1

    See identical proteins and their annotated locations for XP_005167808.1

    UniProtKB/TrEMBL
    A0A8M1NJC4, B0S6Z8
    Related
    ENSDARP00000154230.1, ENSDART00000183416.1
    Conserved Domains (2) summary
    cd03796
    Location:38 → 437
    GT1_PIG-A_like; This family is most closely related to the GT1 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate ...
    COG0438
    Location:39 → 409
    RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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