U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LILRA6 leukocyte immunoglobulin like receptor A6 [ Homo sapiens (human) ]

Gene ID: 79168, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
LILRA6provided by HGNC
Official Full Name
leukocyte immunoglobulin like receptor A6provided by HGNC
Primary source
HGNC:HGNC:15495
See related
Ensembl:ENSG00000244482 AllianceGenome:HGNC:15495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ILT5; ILT8; CD85b; ILT-8; LILRB3; LILRB6
Summary
Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in appendix (RPKM 13.1), spleen (RPKM 5.9) and 7 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.42
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54236590..54242790, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57316995..57323579, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_003571054.1 (211366..293785, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 (PATCHES) NW_004166865.1 (210957..217157, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54720754-54721590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54721591-54722426 Neighboring gene uncharacterized LOC124904768 Neighboring gene leukocyte immunoglobulin like receptor B3 Neighboring gene uncharacterized LOC107985279 Neighboring gene LSM14A, SCD6 homolog A (S. cerevisiae) pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54735962-54736715 Neighboring gene uncharacterized LOC107987463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54747703-54748204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54755357-54755974 Neighboring gene leukocyte immunoglobulin like receptor B5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. LILRA6 copy number variation correlates with susceptibility to atopic dermatitis. López-Álvarez MR, et al. Immunogenetics, 2016 Oct. PMID 27333811, Free PMC Article
  2. Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans. Bashirova AA, et al. Immunogenetics, 2023 Jun. PMID 36449053, Free PMC Article
  3. Immunoglobulin-like receptors and the generation of innate immune memory. Al-Moussawy M, et al. Immunogenetics, 2022 Feb. PMID 35034136, Free PMC Article
  4. Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. Hirayasu K, et al. J Hum Genet, 2021 Jul. PMID 33526815
  5. Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair. Bashirova AA, et al. Immunogenetics, 2014 Jan. PMID 24096970, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.
    Title: Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.
  2. Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.
    Title: Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.
  3. LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.
    Title: LILRA6 copy number variation correlates with susceptibility to atopic dermatitis.
  4. LILRA6 copy number variation may influence the level of the activating receptor on the cell surface, potentially affecting signaling upon LILRB3/A6 ligation
    Title: Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
  6. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients
    Title: Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
leukocyte immunoglobulin-like receptor subfamily A member 6
Names
immunoglobulin-like transcript 5
immunoglobulin-like transcript 8
leucocyte Ig-like receptor A6
leukocyte Ig-like receptor
leukocyte immunoglobulin like receptor B3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360167.1 → NP_001347096.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    KC918866
    UniProtKB/Swiss-Prot
    Q6PI73
    UniProtKB/TrEMBL
    U5XHD7, U5XHE4
    Conserved Domains (2) summary
    cd05751
    Location:27 → 118
    Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains
    cl11960
    Location:123 → 217
    Ig; Immunoglobulin domain

  2. NM_024318.5 → NP_077294.3  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_077294.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the supported protein.
    Source sequence(s)
    AC245052
    Consensus CDS
    CCDS42610.1
    UniProtKB/TrEMBL
    A0A0G2JPY1, U5XH19
    Related
    ENSP00000379651.2, ENST00000396365.7
    Conserved Domains (3) summary
    cd05751
    Location:27 → 118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:237 → 296
    IG_like; Immunoglobulin like
    cl11960
    Location:123 → 217
    Ig; Immunoglobulin domain

RNA

  1. NR_104098.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and includes additional 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC245052
    Related
    ENST00000430421.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    54236590..54242790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    211376..217601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011547130.3 → XP_011545432.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X2

    UniProtKB/TrEMBL
    B5ME96
    Conserved Domains (3) summary
    cd05751
    Location:27 → 118
    Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins
    smart00410
    Location:334 → 396
    IG_like; Immunoglobulin like
    cl11960
    Location:123 → 217
    Ig; Immunoglobulin domain

  2. XM_054329707.1 → XP_054185682.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X3

    UniProtKB/TrEMBL
    U5XJZ2

  3. XM_047442916.1 → XP_047298872.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1

RNA

  1. XR_007068732.1 RNA Sequence

  2. XR_007068733.1 RNA Sequence

  3. XR_001756516.2 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    211579..217752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_8

Genomic

  1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

    Range
    191397..217778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

    Range
    213919..217758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    57316995..57323579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322805.1 → XP_054178780.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X3

  2. XM_054322806.1 → XP_054178781.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X5

  3. XM_054322807.1 → XP_054178782.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X6

  4. XM_054322804.1 → XP_054178779.1  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PI73.2 GenPept UniProtKB/Swiss-Prot:Q6PI73

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous