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ugt2a4 UDP glucuronosyltransferase 2 family, polypeptide A4 [ Danio rerio (zebrafish) ]

Gene ID: 791613, updated on 28-Oct-2024

Summary

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Official Symbol
ugt2a4provided by ZNC
Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide A4provided by ZNC
Primary source
ZFIN:ZDB-GENE-080721-23
See related
Ensembl:ENSDARG00000051940 AllianceGenome:ZFIN:ZDB-GENE-080721-23
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-204e18.2
Summary
Predicted to enable glucuronosyltransferase activity. Predicted to be located in membrane. Is expressed in liver. Orthologous to several human genes including UGT2B10 (UDP glucuronosyltransferase family 2 member B10); UGT2B11 (UDP glucuronosyltransferase family 2 member B11); and UGT2B15 (UDP glucuronosyltransferase family 2 member B15). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See ugt2a4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (69926766..69934558, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (69154214..69162006, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene YTH N6-methyladenosine RNA binding protein C1 Neighboring gene fukutin Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A2 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A1 Neighboring gene DnaJ (Hsp40) homolog, subfamily C , member 25 Neighboring gene regulator of G protein signaling 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular evidence for multiple UDP-glucuronosyltransferase gene familes in fish. George SG, et al. Mar Environ Res, 2002 Sep-Dec. PMID 12408571
  2. Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Zhou Z, et al. Aquat Toxicol, 2017 Oct. PMID 28843737
  3. Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. Li C, et al. BMC Evol Biol, 2007 May 2. PMID 17475008, Free PMC Article
  4. Embryo/larval toxicity and transcriptional effects in zebrafish (Danio rerio) exposed to endocrine active riverbed sediments. Viganò L, et al. Environ Sci Pollut Res Int, 2020 Apr. PMID 31942721
  5. Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. Wang Y, et al. Mol Pharmacol, 2014 Jul. PMID 24728488

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP glucuronosyltransferase 2 family, polypeptide A4
NP_001170804.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177333.2 → NP_001170804.2  UDP glucuronosyltransferase 2 family, polypeptide A4 precursor

    Status: VALIDATED

    Source sequence(s)
    CU571335
    UniProtKB/TrEMBL
    A0A8M1NVM9, F1QH37
    Related
    ENSDARP00000111031.1, ENSDART00000124954.3
    Conserved Domains (2) summary
    PHA03392
    Location:255 → 486
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21 → 520
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    69926766..69934558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395248.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    212110..219065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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