PTGS2 prostaglandin-endoperoxide synthase 2 [Equus caballus (horse)] - Gene

Summary

Official Symbol: PTGS2provided by VGNC
Official Full Name: prostaglandin-endoperoxide synthase 2provided by VGNC
Primary source: VGNC:VGNC:21997
See related: Ensembl:ENSECAG00000017181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: COX-2; PGH2S; PGHS2; PGHS-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
103	current	EquCab3.0 (GCF_002863925.1)	5	NC_009148.3 (20490104..20497088, complement)
102	previous assembly	EquCab2.0 (GCF_000002305.2)	5	NC_009148.2 (23249149..23256133, complement)

Chromosome 5 - NC_009148.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that COX-1 and COX-2 in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.
Title: Expression of cyclo-oxygenases-1 and -2, and microsomal prostaglandin E synthase-1 in penile and preputial papillomas and squamous cell carcinomas in the horse.
Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor, and cyclooxygenase 2 in fetal membranes and endometrium.
Title: Progestin treatment does not affect expression of cytokines, steroid receptors, oxytocin receptor, and cyclooxygenase 2 in fetal membranes and endometrium from pony mares at parturition.
mRNA transcription of prostaglandin synthases and their products in the equine endometrium in the course of fibrosis.
Title: mRNA transcription of prostaglandin synthases and their products in the equine endometrium in the course of fibrosis.
COX-1 and COX-2 genes were constitutively expressed in baseline samples. Low-flow ischemia resulted in significant upregulation of COX-2 gene expression at each subsequent time point, compared with baseline values.
Title: Expression of cyclooxygenase genes in the jejunum of horses during low-flow ischemia and reperfusion.
In this study, both COX-1 and COX-2 were expressed in the colon before induced ischemia; ischemic injury increased expression of COX-2.
Title: Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses.
The effects of semen extender and seminal plasma on the expression of inflammatory modulators in the endometrium of mares are reported.
Title: Influence of different semen extenders and seminal plasma on PMN migration and on expression of IL-1beta, IL-6, TNF-alpha and COX-2 mRNA in the equine endometrium.
The role for p38 mitogen-activated kinase (MAPK) in the signaling mechanism regulating pro-inflammatory cyclooxygenase (COX) gene expression in lipopolysaccharide (LPS)-activated equine leukocytes in horses is reported.
Title: The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes.
It was found that most equine squamous-cell carcinomas and many melanomas appear to express COX-2 and thus could respond to COX-2 inhibitor therapy.
Title: Cyclooxygenase-2 expression in equine tumors.
immunoreactivity in equine ocular squamous-cell carcinoma
Title: Cyclooxygenase-2 immunoreactivity in equine ocular squamous-cell carcinoma.
Immunoreactivity for COX-1 and COX-2 is high in equine corneal SCC, possibly indicating that COX plays a role in oncogenesis or progression of this tumor type at this site.
Title: Immunohistochemical evaluation of cyclooxygenase expression in corneal squamous cell carcinoma in horses.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

GDB:455285 (e-PCR)
- UniSTS:157459

PTGS2-235F (e-PCR)
- UniSTS:15725

PTGS2 (e-PCR)
- UniSTS:503761

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cyclooxygenase pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostaglandin G/H synthase 2

Names: PGH synthase 2; PHS II; cyclooxygenase-2; prostaglandin H2 synthase 2

NP_001075244.1

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081775.2 → NP_001075244.1 prostaglandin G/H synthase 2 precursor

See identical proteins and their annotated locations for NP_001075244.1

Status: VALIDATED

Source sequence(s)

AF027334, CD528418

UniProtKB/Swiss-Prot

O19183

UniProtKB/TrEMBL

A0A5S7N7I1

Related

ENSECAP00000015107.2, ENSECAT00000018514.4

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

pfam00008
Location:21 → 53

EGF; EGF-like domain