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Fdxr ferredoxin reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 79122, updated on 2-Nov-2024

Summary

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Official Symbol
Fdxrprovided by RGD
Official Full Name
ferredoxin reductaseprovided by RGD
Primary source
RGD:621648
See related
EnsemblRapid:ENSRNOG00000058497 AllianceGenome:RGD:621648
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AR
Summary
Enables NADPH binding activity and NADPH-adrenodoxin reductase activity. Involved in NADPH oxidation. Located in mitochondrion. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 3568.8) See more
Orthologs
human mouse all
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Genomic context

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See Fdxr in Genome Data Viewer
Location:
10q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101006845..101015582, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100507863..100516649, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103817724..103826413, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 104 Neighboring gene uncharacterized LOC134480900 Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene uncharacterized LOC134480901 Neighboring gene fatty acid desaturase 6 Neighboring gene USH1 protein network component sans

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential capacity for cholesterol transport and processing in large and small rat luteal cells. McLean MP, et al. Endocrinology, 1992 Nov. PMID 1425418
  2. cDNA cloning, overproduction and characterization of rat adrenodoxin reductase. Sagara Y, et al. Biochim Biophys Acta, 1999 Oct 12. PMID 10525147
  3. Induction and mitochondrial localization of cytochrome P450scc system enzymes in normal and transformed ovarian granulosa cells. Hanukoglu I, et al. J Cell Biol, 1990 Oct. PMID 2170421, Free PMC Article
  4. Androgen synthesis in adrenarche. Miller WL. Rev Endocr Metab Disord, 2009 Mar. PMID 18821018
  5. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, et al. Can J Cardiol, 2012 Nov-Dec. PMID 22721676

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADPH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH-adrenodoxin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH-adrenodoxin reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NADPH oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NADPH oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADPH:adrenodoxin oxidoreductase, mitochondrial
Names
adrenodoxin reductase
ferredoxin--NADP(+) reductase
NP_077067.1
XP_038942839.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024153.1 → NP_077067.1  NADPH:adrenodoxin oxidoreductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_077067.1

    Status: PROVISIONAL

    Source sequence(s)
    D63761
    UniProtKB/Swiss-Prot
    P56522
    UniProtKB/TrEMBL
    A0A8I6G2P7, A6HKL4
    Related
    ENSRNOP00000075248.1, ENSRNOT00000085636.3
    Conserved Domains (2) summary
    PLN02852
    Location:20 → 489
    PLN02852; ferredoxin-NADP+ reductase
    pfam13450
    Location:45 → 90
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101006845..101015582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086911.2 → XP_038942839.1  NADPH:adrenodoxin oxidoreductase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl30539
    Location:27 → 243
    PLN02852; ferredoxin-NADP+ reductase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56522.1 GenPept UniProtKB/Swiss-Prot:P56522

Gene LinkOut

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