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cyp11c1 cytochrome P450, family 11, subfamily C, polypeptide 1 [ Danio rerio (zebrafish) ]

Gene ID: 791124, updated on 2-Nov-2024

Summary

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Official Symbol
cyp11c1provided by ZNC
Official Full Name
cytochrome P450, family 11, subfamily C, polypeptide 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070828-1
See related
Ensembl:ENSDARG00000042014 AllianceGenome:ZFIN:ZDB-GENE-070828-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cyp11b2
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and steroid 11-beta-monooxygenase activity. Acts upstream of or within cortisol metabolic process; male gonad development; and mating behavior. Predicted to be located in membrane and synapse. Predicted to be active in mitochondrial inner membrane. Is expressed in Leydig cell; brain; and pleuroperitoneal region. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cyp11c1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54459131..54471295, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54639247..54653906, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Neighboring gene pyruvate kinase L/R Neighboring gene CDC-like kinase 2b Neighboring gene cAMP responsive element binding protein 3-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Lycium barbarum polysaccharide alleviates nonylphenol exposure induced testicular injury in juvenile zebrafish. Tang ZY, et al. Int J Biol Macromol, 2017 Nov. PMID 28636878
  2. Environmental level of the antidepressant venlafaxine induces behavioral disorders through cortisol in zebrafish larvae (Danio rerio). Tang Y, et al. Neurotoxicol Teratol, 2021 Jan-Feb. PMID 33220437
  3. Physiological roles of glucocorticoids during early embryonic development of the zebrafish (Danio rerio). Wilson KS, et al. J Physiol, 2013 Dec 15. PMID 24167225, Free PMC Article
  4. Anti-Müllerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males. Wang XG, et al. Dev Dyn, 2007 May. PMID 17393497
  5. Cortisol regulates sodium homeostasis by stimulating the transcription of sodium-chloride transporter (NCC) in zebrafish (Danio rerio). Lin CH, et al. Mol Cell Endocrinol, 2016 Feb 15. PMID 26678829

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
    Title: Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
  2. Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
    Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables steroid 11-beta-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to peptide hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortisol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cortisol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in glucocorticoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 11C1
Names
cyp11b
cytochrome P450, family 11, subfamily B, polypeptide 2
cytochrome P45011B
NP_001073673.1
XP_017206857.1
XP_021322434.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080204.1 → NP_001073673.1  cytochrome P450 11C1

    See identical proteins and their annotated locations for NP_001073673.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ650710
    UniProtKB/TrEMBL
    A0A8M1NCP3, A1XRK1
    Related
    ENSDARP00000150599.1, ENSDART00000185978.1
    Conserved Domains (1) summary
    pfam00067
    Location:43 → 511
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    54459131..54471295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466759.2 → XP_021322434.1  cytochrome P450 11C1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PD87
    Conserved Domains (2) summary
    pfam00067
    Location:225 → 693
    p450; Cytochrome P450
    pfam05835
    Location:1 → 125
    Synaphin; Synaphin protein

  2. XM_017351368.3 → XP_017206857.1  cytochrome P450 11C1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YV96
    Related
    ENSDARP00000061571.5, ENSDART00000061572.6
Nucleotide Protein
Heading Accession and Version

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