U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C1orf116 chromosome 1 open reading frame 116 [ Homo sapiens (human) ]

Gene ID: 79098, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C1orf116provided by HGNC
Official Full Name
chromosome 1 open reading frame 116provided by HGNC
Primary source
HGNC:HGNC:28667
See related
Ensembl:ENSG00000182795 MIM:611680; AllianceGenome:HGNC:28667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARG
Summary
Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung (RPKM 46.8), esophagus (RPKM 46.0) and 10 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207018522..207032756, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206283713..206297960, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207191867..207206101, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207192892-207194091 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 4428 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207224117-207224687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207225911-207226550 Neighboring gene YOD1 deubiquitinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. Parsana P, et al. BMC Cancer, 2017 Jun 26. PMID 28651527, Free PMC Article
  2. Both androgen receptor and glucocorticoid receptor are able to induce prostate-specific antigen expression, but differ in their growth-stimulating properties of LNCaP cells. Cleutjens CB, et al. Endocrinology, 1997 Dec. PMID 9389513
  3. A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron. Steketee K, et al. J Mol Endocrinol, 2004 Oct. PMID 15525603
  4. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. Brown KA, et al. J Cell Biochem, 2008 Oct 1. PMID 18729074, Free PMC Article
  5. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARG mRNA expression is high in prostate tissue. SARG is composed of four exons and spans a region of 14.5 kbp on chromosome 1q32.2.
    Title: A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC2742, MGC4309, FLJ36507, DKFZp666H2010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
specifically androgen-regulated gene protein
Names
specifically androgen-regulated protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083924.2 → NP_001077393.1  specifically androgen-regulated gene protein isoform 2

    See identical proteins and their annotated locations for NP_001077393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon at its 5' end, compared to variant 1, producing a distinct 5' UTR and causing translation initiation at a downstream AUG. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC098935, BG150416, DA859157
    Consensus CDS
    CCDS44306.1
    UniProtKB/Swiss-Prot
    Q9BW04
    Related
    ENSP00000436862.1, ENST00000461135.2
    Conserved Domains (1) summary
    pfam15385
    Location:1 → 355
    SARG; Specifically androgen-regulated gene protein

  2. NM_023938.6 → NP_076427.2  specifically androgen-regulated gene protein isoform 1

    See identical proteins and their annotated locations for NP_076427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098935, BC000765, BG150416, DA859157
    Consensus CDS
    CCDS1475.1
    UniProtKB/Swiss-Prot
    C9JV41, Q658X3, Q9BW04
    Related
    ENSP00000352447.5, ENST00000359470.6
    Conserved Domains (1) summary
    pfam15385
    Location:40 → 601
    SARG; Specifically androgen-regulated gene protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    207018522..207032756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509973.3 → XP_011508275.1  specifically androgen-regulated gene protein isoform X2

    See identical proteins and their annotated locations for XP_011508275.1

    UniProtKB/Swiss-Prot
    Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:1 → 355
    SARG; Specifically androgen-regulated gene protein

  2. XM_006711530.2 → XP_006711593.1  specifically androgen-regulated gene protein isoform X1

    See identical proteins and their annotated locations for XP_006711593.1

    UniProtKB/Swiss-Prot
    C9JV41, Q658X3, Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:40 → 601
    SARG; Specifically androgen-regulated gene protein

  3. XM_005273259.2 → XP_005273316.1  specifically androgen-regulated gene protein isoform X2

    See identical proteins and their annotated locations for XP_005273316.1

    UniProtKB/Swiss-Prot
    Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:1 → 355
    SARG; Specifically androgen-regulated gene protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206283713..206297960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338684.1 → XP_054194659.1  specifically androgen-regulated gene protein isoform X1

  2. XM_054338686.1 → XP_054194661.1  specifically androgen-regulated gene protein isoform X2

  3. XM_054338685.1 → XP_054194660.1  specifically androgen-regulated gene protein isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BW04.2 GenPept UniProtKB/Swiss-Prot:Q9BW04

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous