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PVRIG PVR related immunoglobulin domain containing [ Homo sapiens (human) ]

Gene ID: 79037, updated on 16-Mar-2024

Summary

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Official Symbol
PVRIGprovided by HGNC
Official Full Name
PVR related immunoglobulin domain containingprovided by HGNC
Primary source
HGNC:HGNC:32190
See related
Ensembl:ENSG00000213413 MIM:617012; AllianceGenome:HGNC:32190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD112R; C7orf15
Summary
Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 13.9), spleen (RPKM 12.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100219248..100221490)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101459061..101461299)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99816871..99819113)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18425 Neighboring gene 60S ribosomal protein L29-like Neighboring gene glypican 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26344 Neighboring gene STAG3 cohesin complex component Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26345 Neighboring gene CASTOR family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99844389-99845186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99845985-99846781 Neighboring gene uncharacterized LOC105375426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99866902-99867424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99867949-99868470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18429 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99886514-99886677 Neighboring gene speedy/RINGO cell cycle regulator family member E3 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia. Li J, et al. Haematologica, 2021 Dec 1. PMID 33147937, Free PMC Article
  2. Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer. Yang C, et al. Mod Pathol, 2023 Apr. PMID 36788088
  3. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function. Whelan S, et al. Cancer Immunol Res, 2019 Feb. PMID 30659054, Free PMC Article
  4. Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. Xu F, et al. Cancer Immunol Immunother, 2017 Oct. PMID 28623459, Free PMC Article
  5. COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade. Hansen K, et al. Cancer Immunol Immunother, 2021 Dec. PMID 33903974

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
    Title: Nonredundant Upregulation of CD112R (PVRIG) and PD-1 on Cytotoxic T Lymphocytes Located in T Cell Nests of Colorectal Cancer.
  2. COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
    Title: COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
  3. Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
    Title: Hitting the complexity of the TIGIT-CD96-CD112R-CD226 axis for next-generation cancer immunotherapy.
  4. PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia.
    Title: PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia.
  5. we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant inhibitory signaling pathways.
    Title: PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8(+) T-cell Function.
  6. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells.
    Title: Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions.
  7. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals.
    Title: Identification of CD112R as a novel checkpoint for human T cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2463, MGC104322, MGC138295, MGC138297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein PVRIG
Names
CD112 receptor
nectin-2 receptor
poliovirus receptor related immunoglobulin domain containing
poliovirus receptor-related immunoglobulin domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387134.1 → NP_001374063.1  transmembrane protein PVRIG isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005071
    Conserved Domains (2) summary
    cd00096
    Location:23 → 26
    Ig; Ig strand A [structural motif]
    cl11960
    Location:23 → 125
    Ig; Immunoglobulin domain

  2. NM_001397246.1 → NP_001384175.1  transmembrane protein PVRIG isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005071
    Consensus CDS
    CCDS94154.1
    UniProtKB/TrEMBL
    A0A8V8TN58
    Related
    ENSP00000514123.1, ENST00000699088.1
    Conserved Domains (1) summary
    PHA03247
    Location:64 → 304
    PHA03247; large tegument protein UL36; Provisional

  3. NM_024070.3 → NP_076975.2  transmembrane protein PVRIG isoform 1

    See identical proteins and their annotated locations for NP_076975.2

    Status: VALIDATED

    Source sequence(s)
    AC005071, BC073861
    Consensus CDS
    CCDS5690.1
    UniProtKB/Swiss-Prot
    D6W5U9, Q6DKI7, Q9BVK3
    Related
    ENSP00000316675.2, ENST00000317271.3
    Conserved Domains (2) summary
    cl11960
    Location:57 → 145
    Ig; Immunoglobulin domain
    cl26464
    Location:84 → 324
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100219248..100221490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101459061..101461299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DKI7.1 GenPept UniProtKB/Swiss-Prot:Q6DKI7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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