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ZNF655 zinc finger protein 655 [ Homo sapiens (human) ]

Gene ID: 79027, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF655provided by HGNC
Official Full Name
zinc finger protein 655provided by HGNC
Primary source
HGNC:HGNC:30899
See related
Ensembl:ENSG00000197343 MIM:617891; AllianceGenome:HGNC:30899
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VIK; VIK-1
Summary
This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 10.9), lymph node (RPKM 10.0) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF655 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99558642..99576453)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100797976..100815787)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99156265..99174076)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26324 Neighboring gene uncharacterized LOC105375422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26326 Neighboring gene family with sequence similarity 200 member A Neighboring gene transmembrane protein 225B Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99213715-99214694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99227460-99228106 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99236540-99236705 Neighboring gene ADP ribosylation factor 6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF655 is involved in development and progression of non-small-cell lung cancer. Teng Z, et al. Life Sci, 2021 Sep 1. PMID 34144060
  2. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. Houlard M, et al. Oncogene, 2005 Jan 6. PMID 15558030
  3. Sequence diversity and haplotype structure at the human CYP3A cluster. Thompson EE, et al. Pharmacogenomics J, 2006 Mar-Apr. PMID 16314882
  4. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335, Free PMC Article
  5. Zinc finger proteins: new insights into structural and functional diversity. Laity JH, et al. Curr Opin Struct Biol, 2001 Feb. PMID 11179890

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
    Title: ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
  2. ZNF655 is involved in development and progression of non-small-cell lung cancer.
    Title: ZNF655 is involved in development and progression of non-small-cell lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5521, FLJ23461, MGC10859, MGC16203, DKFZp686M1631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 655
Names
vav-1 interacting Kruppel-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029962.1 RefSeqGene

    Range
    5221..23032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009958.1 → NP_001009958.1  zinc finger protein 655 isoform c

    See identical proteins and their annotated locations for NP_001009958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a distinct 5' UTR and an alternate 3' exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    AK027114, BC063478, BE293580
    Consensus CDS
    CCDS34695.1
    UniProtKB/TrEMBL
    C9J9R2
    Related
    ENSP00000396396.1, ENST00000440391.5

  2. NM_001009960.1 → NP_001009960.1  zinc finger protein 655 isoform a

    See identical proteins and their annotated locations for NP_001009960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR and lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
    Source sequence(s)
    AY099353, BC024770, BC037407, BE293580, CR749270
    Consensus CDS
    CCDS5669.1
    UniProtKB/Swiss-Prot
    A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
    Related
    ENSP00000377718.2, ENST00000394163.2
    Conserved Domains (3) summary
    COG5048
    Location:185 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394 → 419
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001083956.2 → NP_001077425.1  zinc finger protein 655 isoform f

    See identical proteins and their annotated locations for NP_001077425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the longest transcript. Variants 7 and 8 encode the longest isoform (f).
    Source sequence(s)
    AK128057, BC024770, BC063478, CR749270, DN993232
    Consensus CDS
    CCDS47655.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000419135.1, ENST00000493277.5
    Conserved Domains (3) summary
    COG5048
    Location:220 → 325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429 → 454
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001085366.2 → NP_001078835.1  zinc finger protein 655 isoform c

    See identical proteins and their annotated locations for NP_001078835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 3' coding exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BM829333
    Consensus CDS
    CCDS34695.1
    UniProtKB/TrEMBL
    C9J9R2
    Related
    ENSP00000350530.2, ENST00000357864.6

  5. NM_001085367.1 → NP_001078836.1  zinc finger protein 655 isoform b

    See identical proteins and their annotated locations for NP_001078836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has a distinct 5' UTR and includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BE293580, BI912391
    Consensus CDS
    CCDS5670.1
    UniProtKB/Swiss-Prot
    Q8N720
    Conserved Domains (2) summary
    smart00349
    Location:77 → 123
    KRAB; krueppel associated box
    pfam01352
    Location:77 → 116
    KRAB; KRAB box

  6. NM_001085368.1 → NP_001078837.1  zinc finger protein 655 isoform f

    See identical proteins and their annotated locations for NP_001078837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 7. Variants 7 and 8 encode the longest isoform (f).
    Source sequence(s)
    AK128057, BC024770, BE293580, BI548533, CR749270
    Consensus CDS
    CCDS47655.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000393876.1, ENST00000424881.5
    Conserved Domains (3) summary
    COG5048
    Location:220 → 325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429 → 454
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001363332.1 → NP_001350261.1  zinc finger protein 655 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005020, AK128057, BC024770, BI548533, CR749270, DC418016
    Consensus CDS
    CCDS47655.1
    Conserved Domains (3) summary
    COG5048
    Location:220 → 325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429 → 454
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001363333.1 → NP_001350262.1  zinc finger protein 655 isoform f

    Status: REVIEWED

    Source sequence(s)
    AK128057, BC024770, BI548533, CR749270, DA314253
    Consensus CDS
    CCDS47655.1
    Conserved Domains (3) summary
    COG5048
    Location:220 → 325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367 → 387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429 → 454
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001363334.1 → NP_001350263.1  zinc finger protein 655 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC005020, AK128057, BC024770, BI548533, CR749270, CV030898, DC418016
    Consensus CDS
    CCDS5669.1
    UniProtKB/Swiss-Prot
    A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
    Conserved Domains (3) summary
    COG5048
    Location:185 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394 → 419
    zf-H2C2_2; Zinc-finger double domain

  10. NM_024061.4 → NP_076966.1  zinc finger protein 655 isoform b

    See identical proteins and their annotated locations for NP_076966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BC063478
    Consensus CDS
    CCDS5670.1
    UniProtKB/Swiss-Prot
    Q8N720
    Related
    ENSP00000322363.5, ENST00000320583.9
    Conserved Domains (2) summary
    smart00349
    Location:77 → 123
    KRAB; krueppel associated box
    pfam01352
    Location:77 → 116
    KRAB; KRAB box

  11. NM_138494.3 → NP_612503.1  zinc finger protein 655 isoform a

    See identical proteins and their annotated locations for NP_612503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
    Source sequence(s)
    AK128057, BC024770, BC037407, BC063478, CR749270
    Consensus CDS
    CCDS5669.1
    UniProtKB/Swiss-Prot
    A4D291, A6NGD3, B4E3M4, B7Z9Q9, D6W5T4, Q8IV00, Q8N720, Q8TA89, Q96EZ3, Q9BQ85
    Related
    ENSP00000252713.4, ENST00000252713.9
    Conserved Domains (3) summary
    COG5048
    Location:185 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394 → 419
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99558642..99576453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420832.1 → XP_047276788.1  zinc finger protein 655 isoform X4

  2. XM_047420831.1 → XP_047276787.1  zinc finger protein 655 isoform X4

  3. XM_047420828.1 → XP_047276784.1  zinc finger protein 655 isoform X1

  4. XM_047420829.1 → XP_047276785.1  zinc finger protein 655 isoform X2

  5. XM_047420830.1 → XP_047276786.1  zinc finger protein 655 isoform X3

    UniProtKB/TrEMBL
    Q68DU4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100797976..100815787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358994.1 → XP_054214969.1  zinc finger protein 655 isoform X4

  2. XM_054358993.1 → XP_054214968.1  zinc finger protein 655 isoform X4

  3. XM_054358990.1 → XP_054214965.1  zinc finger protein 655 isoform X1

  4. XM_054358991.1 → XP_054214966.1  zinc finger protein 655 isoform X2

  5. XM_054358992.1 → XP_054214967.1  zinc finger protein 655 isoform X3

    UniProtKB/TrEMBL
    Q68DU4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009956.1: Suppressed sequence

    Description
    NM_001009956.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001009957.1: Suppressed sequence

    Description
    NM_001009957.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N720.3 GenPept UniProtKB/Swiss-Prot:Q8N720

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