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Mcam melanoma cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 78967, updated on 17-Aug-2024

Summary

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Official Symbol
Mcamprovided by RGD
Official Full Name
melanoma cell adhesion moleculeprovided by RGD
Primary source
RGD:620463
See related
EnsemblRapid:ENSRNOG00000007726 AllianceGenome:RGD:620463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CD146; Muc18
Summary
Involved in positive regulation of cell migration. Located in extracellular space and nucleus. Biomarker of impotence and malignant mesothelioma. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 474.8), Heart (RPKM 232.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mcam in Genome Data Viewer
Location:
8q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53376225..53384407)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44479391..44487575)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48472824..48481005)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094132 Neighboring gene ring finger protein 26 Neighboring gene Cbl proto-oncogene Neighboring gene dynein regulatory complex subunit 12 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4. Marr N, et al. Int J Mol Sci, 2021 Sep 8. PMID 34575887, Free PMC Article
  2. Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure. Yamchi NN, et al. Cell Biochem Funct, 2021 Dec. PMID 34477225
  3. Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy. Obara M, et al. Mol Cell Biochem, 2021 May. PMID 33515199
  4. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. Liu G, et al. PLoS One, 2013. PMID 24023647, Free PMC Article
  5. Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells. Adachi K, et al. Oncol Rep, 2010 Dec. PMID 21042736

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
    Title: Menstrual blood CD146(+) mesenchymal stem cells reduced fibrosis rate in the rat model of premature ovarian failure.
  2. CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-alpha4.
    Title: CD146 Delineates an Interfascicular Cell Sub-Population in Tendon That Is Recruited during Injury through Its Ligand Laminin-α4.
  3. Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
    Title: Expression of cell adhesion molecule, Gicerin/CD146 during the formation of heart and in the cardiac hypertrophy.
  4. Alterations in CD146 are involved in the basic etiology of COPD/pulmonary emphysema.
    Title: Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD.
  5. Gicerin might promote the interaction of tumor cells with a hepatic endothelium, thus leading to the hepatic metastasis of colon adenocarcinomas.
    Title: Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells.
  6. Increase of gicerin expression by NGF promotes the gicerin-gicerin homophilic interaction resulting in the neurite extension.
    Title: Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells.
  7. expression of gicerin was increased in the rat carotid arteries after balloon injury. Gicerin might be involved in the arteriosclerotic neointima formation in the artery.
    Title: Induction of gicerin/CD146 in the rat carotid artery after balloon injury.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell surface glycoprotein MUC18
Names
gicerin
l-gicerin
melanoma-associated antigen MUC18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034009.1 → NP_001029181.1  cell surface glycoprotein MUC18 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001029181.1

    Status: VALIDATED

    Source sequence(s)
    BC070916
    UniProtKB/TrEMBL
    A0A8I6AFJ0, A6J3W1
    Related
    ENSRNOP00000069860.1, ENSRNOT00000090780.3
    Conserved Domains (4) summary
    pfam08205
    Location:141 → 236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:348 → 412
    Ig_3; Immunoglobulin domain
    cd00096
    Location:172 → 177
    Ig; Ig strand C [structural motif]
    cl11960
    Location:452 → 508
    Ig; Immunoglobulin domain

  2. NM_023983.3 → NP_076473.2  cell surface glycoprotein MUC18 isoform 1 precursor

    See identical proteins and their annotated locations for NP_076473.2

    Status: VALIDATED

    Source sequence(s)
    AB035506, BC070916
    UniProtKB/Swiss-Prot
    Q6IRH8, Q9EPF2, Q9ESS8
    UniProtKB/TrEMBL
    A0A8I6AFJ0, A6J3W0
    Related
    ENSRNOP00000010464.5, ENSRNOT00000010463.8
    Conserved Domains (4) summary
    smart00408
    Location:359 → 412
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:440 → 515
    IG_like; Immunoglobulin like
    pfam08205
    Location:141 → 236
    C2-set_2; CD80-like C2-set immunoglobulin domain
    cl11960
    Location:452 → 515
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53376225..53384407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPF2.2 GenPept UniProtKB/Swiss-Prot:Q9EPF2

Gene LinkOut

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