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Nadsyn1 NAD synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 78914, updated on 2-Nov-2024

Summary

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Official Symbol
Nadsyn1provided by MGI
Official Full Name
NAD synthetase 1provided by MGI
Primary source
MGI:MGI:1926164
See related
Ensembl:ENSMUSG00000031090 AllianceGenome:MGI:1926164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130012B15Rik
Summary
Predicted to enable NAD+ synthase (glutamine-hydrolyzing) activity; NAD+ synthase activity; and glutaminase activity. Predicted to be involved in 'de novo' NAD biosynthetic process. Predicted to be active in cytoplasm. Is expressed in alimentary system; liver; male reproductive gland or organ; metanephros; and nervous system. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human NADSYN1 (NAD synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 18.4), large intestine adult (RPKM 18.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nadsyn1 in Genome Data Viewer
Location:
7 F5; 7 88.32 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143349326..143376598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143795589..143822862, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member G Neighboring gene MAS-related GPR, member E Neighboring gene STARR-positive B cell enhancer ABC_E1750 Neighboring gene STARR-positive B cell enhancer ABC_E2257 Neighboring gene STARR-positive B cell enhancer ABC_E3763 Neighboring gene 7-dehydrocholesterol reductase Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:151023918-151024190 Neighboring gene STARR-seq mESC enhancer starr_20537 Neighboring gene actin, epsilon 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome. Marin TL, et al. BMC Syst Biol, 2015 Mar 11. PMID 25890336, Free PMC Article
  2. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder. Szot JO, et al. J Clin Invest, 2024 Feb 15. PMID 38357931, Free PMC Article
  3. Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. Hara N, et al. J Biol Chem, 2003 Mar 28. PMID 12547821
  4. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. Yaku K, et al. Nat Commun, 2021 Nov 19. PMID 34799586, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
    Title: A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables NAD+ synthase (glutamine-hydrolyzing) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD+ synthase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glutaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' NAD biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in NAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamine-dependent NAD(+) synthetase
Names
NAD(+) synthase
NH3-dependent NAD(+) synthetase-like protein
NP_001295024.1
NP_084497.1
XP_006508718.1
XP_011240323.1
XP_011240325.1
XP_017167890.1
XP_030098977.1
XP_030098978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308095.1 → NP_001295024.1  glutamine-dependent NAD(+) synthetase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in its 5' UTR, resulting in the use of a downstream in-frame start site, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AK020264, BQ176832, BY035654
    UniProtKB/Swiss-Prot
    Q711T7
    Conserved Domains (1) summary
    PLN02339
    Location:1 → 451
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  2. NM_030221.2 → NP_084497.1  glutamine-dependent NAD(+) synthetase isoform 1

    See identical proteins and their annotated locations for NP_084497.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK020264, BQ176832, BY035654
    Consensus CDS
    CCDS22047.1
    UniProtKB/Swiss-Prot
    Q711P6, Q711T7, Q8CFY6, Q9D280
    Related
    ENSMUSP00000033415.9, ENSMUST00000033415.15
    Conserved Domains (3) summary
    cd07570
    Location:6 → 287
    GAT_Gln-NAD-synth; Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases)
    PLN02339
    Location:3 → 697
    PLN02339; NAD+ synthase (glutamine-hydrolysing)
    cd00553
    Location:328 → 650
    NAD_synthase; NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143349326..143376598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243118.2 → XP_030098978.1  glutamine-dependent NAD(+) synthetase isoform X5

    Conserved Domains (1) summary
    PLN02339
    Location:1 → 451
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  2. XM_011242021.4 → XP_011240323.1  glutamine-dependent NAD(+) synthetase isoform X1

    See identical proteins and their annotated locations for XP_011240323.1

    UniProtKB/Swiss-Prot
    Q711T7
    Conserved Domains (1) summary
    PLN02339
    Location:1 → 610
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  3. XM_017312401.3 → XP_017167890.1  glutamine-dependent NAD(+) synthetase isoform X2

    Conserved Domains (1) summary
    PLN02339
    Location:1 → 583
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  4. XM_030243117.2 → XP_030098977.1  glutamine-dependent NAD(+) synthetase isoform X5

    Conserved Domains (1) summary
    PLN02339
    Location:1 → 451
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  5. XM_006508655.5 → XP_006508718.1  glutamine-dependent NAD(+) synthetase isoform X3

    UniProtKB/TrEMBL
    G5E8V4
    Related
    ENSMUSP00000114380.2, ENSMUST00000132520.8
    Conserved Domains (1) summary
    PLN02339
    Location:3 → 485
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

  6. XM_011242023.4 → XP_011240325.1  glutamine-dependent NAD(+) synthetase isoform X4

    See identical proteins and their annotated locations for XP_011240325.1

    UniProtKB/TrEMBL
    G5E8V4
    Conserved Domains (1) summary
    PLN02339
    Location:3 → 486
    PLN02339; NAD+ synthase (glutamine-hydrolysing)

RNA

  1. XR_378612.4 RNA Sequence

  2. XR_004934222.1 RNA Sequence

    Related
    ENSMUST00000156638.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001308092.1: Suppressed sequence

    Description
    NM_001308092.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q711T7.1 GenPept UniProtKB/Swiss-Prot:Q711T7

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