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Spaca7 sperm acrosome associated 7 [ Mus musculus (house mouse) ]

Gene ID: 78634, updated on 28-Oct-2024

Summary

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Official Symbol
Spaca7provided by MGI
Official Full Name
sperm acrosome associated 7provided by MGI
Primary source
MGI:MGI:1925884
See related
Ensembl:ENSMUSG00000010435 AllianceGenome:MGI:1925884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700094C09Rik
Summary
Acts upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human SPACA7 (sperm acrosome associated 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward testis adult (RPKM 51.2) See more
Orthologs
human all
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Genomic context

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See Spaca7 in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12623038..12650744)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12573036..12600739)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20739 Neighboring gene predicted gene, 33532 Neighboring gene STARR-seq mESC enhancer starr_20743 Neighboring gene predicted gene, 53397 Neighboring gene STARR-seq mESC enhancer starr_20744 Neighboring gene tubulin, gamma complex component 3 Neighboring gene STARR-seq mESC enhancer starr_20746 Neighboring gene RIKEN cDNA 4931415C17 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SPACA7 is a novel male germ cell-specific protein localized to the sperm acrosome that is involved in fertilization in mice. Nguyen EB, et al. Biol Reprod, 2014 Jan. PMID 24307706, Free PMC Article
  2. Identification of a new mouse sperm acrosome-associated protein. Korfanty J, et al. Reproduction, 2012 Jun. PMID 22495889
  3. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
  4. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC58425

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm acrosome-associated protein 7
Names
protein SPACA7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357297.2 → NP_001344226.1  sperm acrosome-associated protein 7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC161505
    Consensus CDS
    CCDS90371.1
    UniProtKB/TrEMBL
    I6L9C9
    Related
    ENSMUSP00000147552.2, ENSMUST00000209428.2
    Conserved Domains (1) summary
    pfam15307
    Location:19 → 122
    SPACA7; Sperm acrosome-associated protein 7

  2. NM_024279.4 → NP_077241.1  sperm acrosome-associated protein 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_077241.1

    Status: VALIDATED

    Source sequence(s)
    AC161505
    Consensus CDS
    CCDS40222.1
    UniProtKB/Swiss-Prot
    Q9D2S4
    UniProtKB/TrEMBL
    A0A1B0GRZ1
    Related
    ENSMUSP00000010579.7, ENSMUST00000010579.8
    Conserved Domains (1) summary
    pfam15307
    Location:19 → 130
    SPACA7; Sperm acrosome-associated protein 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    12623038..12650744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2S4.1 GenPept UniProtKB/Swiss-Prot:Q9D2S4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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