Zfp449 zinc finger protein 449 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp449provided by MGI
Official Full Name: zinc finger protein 449provided by MGI
Primary source: MGI:MGI:1925869
See related: Ensembl:ENSMUSG00000073176 AllianceGenome:MGI:1925869
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9530049C15Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within spermatogonial cell division. Is expressed in several structures, including central nervous system; connective tissue; gut; skeletal system; and urinary system. Orthologous to human ZNF449 (zinc finger protein 449). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 2.2), bladder adult (RPKM 1.6) and 21 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: X A5; X 30.06 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (55391757..55411034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (56346397..56365674)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogonial cell division	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: zinc finger protein 449

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359276.1 → NP_001346205.1 zinc finger protein 449 isoform 2

Status: VALIDATED

Source sequence(s)

AL683799, BC082594, CR954970, CR955029

Conserved Domains (3) summary

COG5048
Location:203 → 354

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:205 → 225

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:357 → 382

zf-H2C2_2; Zinc-finger double domain
NM_030139.5 → NP_084415.1 zinc finger protein 449 isoform 1

See identical proteins and their annotated locations for NP_084415.1

Status: VALIDATED

Source sequence(s)

AK036596, AK142888, BB527216, BC082594

Consensus CDS

CCDS30143.1

UniProtKB/TrEMBL

Q8CB76

Related

ENSMUSP00000099096.4, ENSMUST00000101560.4

Conserved Domains (6) summary

smart00431
Location:27 → 134

SCAN; leucine rich region

COG5048
Location:323 → 483

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:325 → 345

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:323 → 345

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:27 → 113

SCAN; SCAN domain

pfam13465
Location:421 → 446

zf-H2C2_2; Zinc-finger double domain