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IL1R2 interleukin 1 receptor type 2 [ Homo sapiens (human) ]

Gene ID: 7850, updated on 3-Apr-2024

Summary

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Official Symbol
IL1R2provided by HGNC
Official Full Name
interleukin 1 receptor type 2provided by HGNC
Primary source
HGNC:HGNC:5994
See related
Ensembl:ENSG00000115590 MIM:147811; AllianceGenome:HGNC:5994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1RB; CD121b; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2
Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
Expression
Biased expression in appendix (RPKM 4.1), bone marrow (RPKM 3.4) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
2q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101991960..102028544)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102450049..102486842)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102608422..102645006)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16304 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:102358485-102359214 Neighboring gene Sharpr-MPRA regulatory region 8953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102422933-102423868 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102424513-102425121 Neighboring gene Sharpr-MPRA regulatory region 3767 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:102509916-102510686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:102552199-102552715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102599375-102599875 Neighboring gene long intergenic non-protein coding RNA 1127 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102637443-102637636 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance. Chen Q, et al. Anatol J Cardiol, 2022 Sep. PMID 35943312, Free PMC Article
  2. IL1R2 polymorphisms and their interaction are associated with osteoporosis susceptibility in the Chinese Han population. Rong K, et al. Int J Immunogenet, 2021 Dec. PMID 34664761
  3. Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer. Pequeno DP, et al. J Holist Nurs, 2022 Sep. PMID 34636689
  4. IL-1R2 expression in human gastric cancer and its clinical significance. Yuan M, et al. Biosci Rep, 2021 Mar 26. PMID 33704402, Free PMC Article
  5. Platelet concentrate and type II IL-1 receptor are risk factors for allergic transfusion reactions in children. Hu W, et al. Ital J Pediatr, 2020 Jul 29. PMID 32727543, Free PMC Article

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1alpha/PFKFB3 pathway.
    Title: IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.
  2. Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
    Title: Il1r2 and Tnfrsf12a in transcranial magnetic stimulation effect of ischemic stroke via bioinformatics analysis.
  3. Expression of interleukin-1beta and its receptor in human granulosa cells and their association with steroidogenesis.
    Title: Expression of interleukin-1β and its receptor in human granulosa cells and their association with steroidogenesis.
  4. Single-cell analysis reveals novel clonally expanded monocytes associated with IL1beta-IL1R2 pair in acute inflammatory demyelinating polyneuropathy.
    Title: Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β-IL1R2 pair in acute inflammatory demyelinating polyneuropathy.
  5. Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
    Title: Decreased Expression of EZH2 in Granulosa Cells Contributes to Endometriosis-Associated Infertility by Targeting IL-1R2.
  6. Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance.
    Title: Over-expression of IL1R2 in PBMCs of Patients with Coronary Artery Disease and Its Clinical Significance.
  7. Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer.
    Title: Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer.
  8. Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
    Title: Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis.
  9. Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.
    Title: Association of ITPKB, IL1R2 and COQ7 with Parkinson's disease in Taiwan.
  10. Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1beta-dependent response of Th17 cells.
    Title: Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1β-dependent response of Th17 cells.
Submit: New GeneRIF Correction See all GeneRIFs (79)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
EBI GWAS Catalog
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47725

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1 alpha production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor type 2
Names
CD121 antigen-like family member B
IL-1 type II receptor
IL-1R-beta
antigen CDw121b
interleukin-1 receptor beta
interleukin-1 receptor type II
type II interleukin-1 receptor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261419.2 → NP_001248348.1  interleukin-1 receptor type 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001248348.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' splice site which introduces an immediate stop codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005035, AC007165, U64094
    Consensus CDS
    CCDS58719.1
    UniProtKB/Swiss-Prot
    P27930
    Related
    ENSP00000414611.1, ENST00000441002.1
    Conserved Domains (4) summary
    cd05756
    Location:30 → 125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:136 → 230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02826
    Location:27 → 228
    PHA02826; IL-1 receptor-like protein; Provisional
    cl11960
    Location:241 → 285
    Ig; Immunoglobulin domain

  2. NM_004633.4 → NP_004624.1  interleukin-1 receptor type 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004624.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007165, BC039031
    Consensus CDS
    CCDS2054.1
    UniProtKB/Swiss-Prot
    D3DVJ5, P27930, Q6LCE6, Q9UE68
    Related
    ENSP00000330959.3, ENST00000332549.8
    Conserved Domains (3) summary
    cd05897
    Location:136 → 230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241 → 341
    ig; Immunoglobulin domain
    cd05756
    Location:30 → 125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

RNA

  1. NR_048564.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005035, AC007165, DC380050, X59770

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101991960..102028544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712736.4 → XP_006712799.1  interleukin-1 receptor type 2 isoform X2

    Conserved Domains (4) summary
    cd05756
    Location:55 → 150
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:161 → 255
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02785
    Location:31 → 352
    PHA02785; IL-beta-binding protein; Provisional
    pfam00047
    Location:266 → 366
    ig; Immunoglobulin domain

  2. XM_006712734.4 → XP_006712797.1  interleukin-1 receptor type 2 isoform X3

    See identical proteins and their annotated locations for XP_006712797.1

    UniProtKB/Swiss-Prot
    D3DVJ5, P27930, Q6LCE6, Q9UE68
    Related
    ENSP00000377066.2, ENST00000393414.6
    Conserved Domains (3) summary
    cd05897
    Location:136 → 230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241 → 341
    ig; Immunoglobulin domain
    cd05756
    Location:30 → 125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  3. XM_011511805.4 → XP_011510107.1  interleukin-1 receptor type 2 isoform X4

    Conserved Domains (3) summary
    cd05897
    Location:116 → 210
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:221 → 321
    ig; Immunoglobulin domain
    cl11960
    Location:53 → 105
    Ig; Immunoglobulin domain

  4. XM_011511804.4 → XP_011510106.1  interleukin-1 receptor type 2 isoform X3

    See identical proteins and their annotated locations for XP_011510106.1

    UniProtKB/Swiss-Prot
    D3DVJ5, P27930, Q6LCE6, Q9UE68
    Conserved Domains (3) summary
    cd05897
    Location:136 → 230
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    pfam00047
    Location:241 → 341
    ig; Immunoglobulin domain
    cd05756
    Location:30 → 125
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

  5. XM_011511801.3 → XP_011510103.1  interleukin-1 receptor type 2 isoform X1

    Conserved Domains (4) summary
    cd05756
    Location:73 → 168
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:179 → 273
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02785
    Location:49 → 370
    PHA02785; IL-beta-binding protein; Provisional
    pfam00047
    Location:284 → 384
    ig; Immunoglobulin domain

  6. XM_047445800.1 → XP_047301756.1  interleukin-1 receptor type 2 isoform X5

  7. XM_011511807.2 → XP_011510109.1  interleukin-1 receptor type 2 isoform X6

    UniProtKB/TrEMBL
    C9JNR0
    Related
    ENSP00000408415.1, ENST00000457817.5
    Conserved Domains (3) summary
    cd05756
    Location:73 → 168
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05897
    Location:179 → 272
    Ig2_IL1R2_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor-2 (IL1R2)
    PHA02826
    Location:70 → 271
    PHA02826; IL-1 receptor-like protein; Provisional

  8. XM_011511808.3 → XP_011510110.1  interleukin-1 receptor type 2 isoform X7

    Conserved Domains (2) summary
    smart00410
    Location:82 → 179
    IG_like; Immunoglobulin like
    pfam00047
    Location:79 → 179
    ig; Immunoglobulin domain

RNA

  1. XR_923024.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    102450049..102486842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343830.1 → XP_054199805.1  interleukin-1 receptor type 2 isoform X2

  2. XM_054343831.1 → XP_054199806.1  interleukin-1 receptor type 2 isoform X3

    UniProtKB/Swiss-Prot
    D3DVJ5, P27930, Q6LCE6, Q9UE68

  3. XM_054343834.1 → XP_054199809.1  interleukin-1 receptor type 2 isoform X8

  4. XM_054343832.1 → XP_054199807.1  interleukin-1 receptor type 2 isoform X4

  5. XM_054343829.1 → XP_054199804.1  interleukin-1 receptor type 2 isoform X1

  6. XM_054343833.1 → XP_054199808.1  interleukin-1 receptor type 2 isoform X5

  7. XM_054343835.1 → XP_054199810.1  interleukin-1 receptor type 2 isoform X6

  8. XM_054343836.1 → XP_054199811.1  interleukin-1 receptor type 2 isoform X7

RNA

  1. XR_008486512.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173343.1: Suppressed sequence

    Description
    NM_173343.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27930.1 GenPept UniProtKB/Swiss-Prot:P27930

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