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DAP3 death associated protein 3 [ Homo sapiens (human) ]

Gene ID: 7818, updated on 5-Mar-2024

Summary

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Official Symbol
DAP3provided by HGNC
Official Full Name
death associated protein 3provided by HGNC
Primary source
HGNC:HGNC:2673
See related
Ensembl:ENSG00000132676 MIM:602074; AllianceGenome:HGNC:2673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mS29; DAP-3; S29mt; MRPS29; MRP-S29; bMRP-10
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in lymph node (RPKM 26.0), appendix (RPKM 24.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155687948..155739010)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154827654..154877880)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155658882..155708801)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like pseudogene Neighboring gene YY1 associated protein 1 Neighboring gene small Cajal body-specific RNA 26A Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155657971-155658605 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1818 Neighboring gene uncharacterized LOC124904431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1819 Neighboring gene misato family member 2, pseudogene Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression. Han J, et al. Sci Adv, 2020 Jun. PMID 32596459, Free PMC Article
  2. Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis. Jia Y, et al. J Investig Med, 2019 Jun. PMID 30792218
  3. Effects of the knockdown of death-associated protein 3 expression on cell adhesion, growth and migration in breast cancer cells. Wazir U, et al. Oncol Rep, 2015 May. PMID 25738636
  4. Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy. Jia Y, et al. Br J Cancer, 2014 Jan 21. PMID 24300973, Free PMC Article
  5. The mRNA expression of DAP3 in human breast cancer: correlation with clinicopathological parameters. Wazir U, et al. Anticancer Res, 2012 Feb. PMID 22287761

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Death associated protein3 (DAP3) and DAP3 binding cell death enhancer1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance.
    Title: Death associated protein‑3 (DAP3) and DAP3 binding cell death enhancer‑1 (DELE1) in human colorectal cancer, and their impacts on clinical outcome and chemoresistance.
  2. Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.
    Title: Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.
  3. Expression of Death Associated Proteins DAP1 and DAP3 in Human Pancreatic Cancer.
    Title: Expression of Death Associated Proteins DAP1 and DAP3 in Human Pancreatic Cancer.
  4. The present findings indicate that DAP3 deficiency-induced chemoresistance in gastric cancer is at least partially mediated through the beta-catenin/LGR5/Bcl-2 axis.
    Title: Depletion of death-associated protein-3 induces chemoresistance in gastric cancer cells through the β-catenin/LGR5/Bcl-2 axis.
  5. DAP3 plays important roles in mitochondrial function and dynamics
    Title: Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
  6. DAP3 silencing contributes to breast carcinogenesis.
    Title: Effects of the knockdown of death-associated protein 3 expression on cell adhesion, growth and migration in breast cancer cells.
  7. Knockdown of DAP3 expression promoted cell migration.
    Title: Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy.
  8. Study demonstrates an inverse association between DAP3 mRNA levels and tumour stage and clinical outcome in breast cancer.
    Title: The mRNA expression of DAP3 in human breast cancer: correlation with clinicopathological parameters.
  9. identified a novel DAP3-binding protein termed death ligand signal enhancer (DELE); results demonstrated the biological significance of DELE for apoptosis signal mediated by death receptors
    Title: Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction.
  10. show that interferon-beta promoter stimulator 1 (IPS-1) binds DAP3 and induces anoikis by caspase activation.
    Title: IPS-1 is crucial for DAP3-mediated anoikis induction by caspase-8 activation.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of death associated protein 3 (DAP3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12817, MGC126058, MGC126059, DKFZp686G12159

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS29
Names
28S ribosomal protein S29, mitochondrial
ionizing radiation resistance conferring protein
mitochondrial 28S ribosomal protein S29
mitochondrial small ribosomal subunit protein mS29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199849.1 → NP_001186778.1  small ribosomal subunit protein mS29 isoform 1

    See identical proteins and their annotated locations for NP_001186778.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AK225869, AK302281, AL162734, BC107487, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    B4DP59, B4DY62, E7EM60, P51398, Q13044, Q68CT7, Q96Q20
    Conserved Domains (1) summary
    pfam10236
    Location:99 → 393
    DAP3; Mitochondrial ribosomal death-associated protein 3

  2. NM_001199850.1 → NP_001186779.1  small ribosomal subunit protein mS29 isoform 2

    See identical proteins and their annotated locations for NP_001186779.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK298201, AK302281, AL162734, BQ183744
    Consensus CDS
    CCDS55646.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000412605.2, ENST00000421487.6
    Conserved Domains (1) summary
    pfam10236
    Location:65 → 359
    DAP3; Mitochondrial ribosomal death-associated protein 3

  3. NM_001199851.1 → NP_001186780.1  small ribosomal subunit protein mS29 isoform 3

    See identical proteins and their annotated locations for NP_001186780.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK298201, AK302281, AL162734, BQ183744
    Consensus CDS
    CCDS55647.1
    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000445003.1, ENST00000535183.5
    Conserved Domains (1) summary
    pfam10236
    Location:58 → 352
    DAP3; Mitochondrial ribosomal death-associated protein 3

  4. NM_004632.4 → NP_004623.1  small ribosomal subunit protein mS29 isoform 1

    See identical proteins and their annotated locations for NP_004623.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (1). Variants 1, 2 and 3 encode the same isoform 1.
    Source sequence(s)
    AL162734, BC107487, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    B4DP59, B4DY62, E7EM60, P51398, Q13044, Q68CT7, Q96Q20
    Related
    ENSP00000357320.5, ENST00000368336.10
    Conserved Domains (1) summary
    pfam10236
    Location:99 → 393
    DAP3; Mitochondrial ribosomal death-associated protein 3

  5. NM_033657.2 → NP_387506.1  small ribosomal subunit protein mS29 isoform 1

    See identical proteins and their annotated locations for NP_387506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an additional segment in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AL162734, BC107488, BQ183744
    Consensus CDS
    CCDS1120.1
    UniProtKB/Swiss-Prot
    B4DP59, B4DY62, E7EM60, P51398, Q13044, Q68CT7, Q96Q20
    Related
    ENSP00000341692.3, ENST00000343043.7
    Conserved Domains (1) summary
    pfam10236
    Location:99 → 393
    DAP3; Mitochondrial ribosomal death-associated protein 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155687948..155739010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430081.1 → XP_047286037.1  small ribosomal subunit protein mS29 isoform X1

    UniProtKB/Swiss-Prot
    B4DP59, B4DY62, E7EM60, P51398, Q13044, Q68CT7, Q96Q20

  2. XM_047430085.1 → XP_047286041.1  small ribosomal subunit protein mS29 isoform X2

  3. XM_047430090.1 → XP_047286046.1  small ribosomal subunit protein mS29 isoform X3

  4. XM_047430096.1 → XP_047286052.1  small ribosomal subunit protein mS29 isoform X5

  5. XM_047430092.1 → XP_047286048.1  small ribosomal subunit protein mS29 isoform X4

  6. XM_024449700.2 → XP_024305468.1  small ribosomal subunit protein mS29 isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:58 → 325
    DAP3; Mitochondrial ribosomal death-associated protein 3

  7. XM_047430087.1 → XP_047286043.1  small ribosomal subunit protein mS29 isoform X2

  8. XM_047430093.1 → XP_047286049.1  small ribosomal subunit protein mS29 isoform X4

  9. XM_024449697.2 → XP_024305465.1  small ribosomal subunit protein mS29 isoform X1

    UniProtKB/Swiss-Prot
    B4DP59, B4DY62, E7EM60, P51398, Q13044, Q68CT7, Q96Q20
    Conserved Domains (1) summary
    pfam10236
    Location:99 → 393
    DAP3; Mitochondrial ribosomal death-associated protein 3

  10. XM_024449698.2 → XP_024305466.1  small ribosomal subunit protein mS29 isoform X2

    Conserved Domains (1) summary
    pfam10236
    Location:99 → 366
    DAP3; Mitochondrial ribosomal death-associated protein 3

  11. XM_017002294.2 → XP_016857783.1  small ribosomal subunit protein mS29 isoform X5

  12. XM_017002292.2 → XP_016857781.1  small ribosomal subunit protein mS29 isoform X4

    UniProtKB/Swiss-Prot
    P51398
    Related
    ENSP00000476592.1, ENST00000471642.6
    Conserved Domains (1) summary
    pfam10236
    Location:58 → 352
    DAP3; Mitochondrial ribosomal death-associated protein 3

  13. XM_017002295.2 → XP_016857784.1  small ribosomal subunit protein mS29 isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:58 → 325
    DAP3; Mitochondrial ribosomal death-associated protein 3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154827654..154877880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338661.1 → XP_054194636.1  small ribosomal subunit protein mS29 isoform X2

  2. XM_054338665.1 → XP_054194640.1  small ribosomal subunit protein mS29 isoform X5

  3. XM_054338667.1 → XP_054194642.1  small ribosomal subunit protein mS29 isoform X6

  4. XM_054338662.1 → XP_054194637.1  small ribosomal subunit protein mS29 isoform X2

  5. XM_054338663.1 → XP_054194638.1  small ribosomal subunit protein mS29 isoform X3

  6. XM_054338666.1 → XP_054194641.1  small ribosomal subunit protein mS29 isoform X5

  7. XM_054338664.1 → XP_054194639.1  small ribosomal subunit protein mS29 isoform X4

  8. XM_054338668.1 → XP_054194643.1  small ribosomal subunit protein mS29 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51398.1 GenPept UniProtKB/Swiss-Prot:P51398

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