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Ascc3 activating signal cointegrator 1 complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 77987, updated on 18-Sep-2024

Summary

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Official Symbol
Ascc3provided by MGI
Official Full Name
activating signal cointegrator 1 complex subunit 3provided by MGI
Primary source
MGI:MGI:1925237
See related
Ensembl:ENSMUSG00000038774 AllianceGenome:MGI:1925237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNAH; Helic1; ASC1p200; D630041L21; B630009I04Rik; D430001L07Rik
Summary
Predicted to enable 3'-5' DNA helicase activity. Predicted to be involved in several processes, including DNA dealkylation involved in DNA repair; DNA duplex unwinding; and cellular protein metabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in cytosol. Predicted to be part of activating signal cointegrator 1 complex. Predicted to be active in nucleus. Is expressed in embryo. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.7), liver E14 (RPKM 3.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ascc3 in Genome Data Viewer
Location:
10 B3; 10 24.87 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (50468756..50727300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (50592663..50851202)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57555 Neighboring gene predicted gene, 46199 Neighboring gene STARR-seq mESC enhancer starr_26642 Neighboring gene STARR-positive B cell enhancer ABC_E8333 Neighboring gene STARR-seq mESC enhancer starr_26643 Neighboring gene STARR-positive B cell enhancer mm9_chr10:50482908-50483208 Neighboring gene ribosomal protein L15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26645 Neighboring gene RIKEN cDNA A230054N11 gene Neighboring gene single-minded family bHLH transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article
  2. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA alkylation repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA duplex unwinding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of DNA repair complex IEA
Inferred from Electronic Annotation
more info
  
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
  
part_of activating signal cointegrator 1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of activating signal cointegrator 1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1 complex subunit 3
Names
helicase, ATP binding 1
NP_932124.2
XP_030101248.1
XP_030101249.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198007.2 → NP_932124.2  activating signal cointegrator 1 complex subunit 3

    See identical proteins and their annotated locations for NP_932124.2

    Status: VALIDATED

    Source sequence(s)
    AC137877, AC153529, AC159114
    Consensus CDS
    CCDS48555.1
    UniProtKB/Swiss-Prot
    E9PZJ8, Q6PB36, Q8C1G1, Q8C707, Q8K292
    Related
    ENSMUSP00000036726.9, ENSMUST00000035606.10
    Conserved Domains (5) summary
    smart00490
    Location:1615 → 1694
    HELICc; helicase superfamily c-terminal domain
    smart00611
    Location:1810 → 2179
    SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
    COG1204
    Location:461 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    pfam00270
    Location:1329 → 1500
    DEAD; DEAD/DEAH box helicase
    pfam02889
    Location:979 → 1287
    Sec63; Sec63 Brl domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    50468756..50727300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245388.2 → XP_030101248.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    Conserved Domains (3) summary
    COG1204
    Location:363 → 1142
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1229 → 1417
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
    pfam18149
    Location:152 → 193
    Helicase_PWI; N-terminal helicase PWI domain

  2. XM_030245389.2 → XP_030101249.1  activating signal cointegrator 1 complex subunit 3 isoform X2

    Conserved Domains (2) summary
    COG1204
    Location:125 → 904
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:991 → 1179
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PZJ8.1 GenPept UniProtKB/Swiss-Prot:E9PZJ8

Gene LinkOut

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