gnai2.S guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gnai2.S
Official Full Name: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 S homeolog
Primary source: Xenbase:XB-GENE-6050865
Locus tag: XELAEV_18025777mg
See related: EnsemblRapid:ENSXLAG00005018607 AllianceGenome:Xenbase:XB-GENE-6050865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Gi2; gip; gnai2; gnai3; gnai2b
Summary: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTP binding activity; and GTPase activity. Predicted to act upstream of or within G protein-coupled adenosine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and gamma-aminobutyric acid signaling pathway. Predicted to be located in centrosome and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in nervous system and urinary system. Orthologous to human GNAI2 (G protein subunit alpha i2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (105796849..105865237)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (99482928..99551499)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
part_of heterotrimeric G-protein complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 S homeolog

Names: G alpha i; guanine nucleotide binding protein, alpha inhibiting 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097056.1 → NP_001090525.1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 S homeolog

See identical proteins and their annotated locations for NP_001090525.1

Status: PROVISIONAL

Source sequence(s)

BC084923

UniProtKB/TrEMBL

O93565, Q5U4X0

Related

ENSXLAP00005054985.1, ENSXLAT00005056173.1

Conserved Domains (2) summary

cd00066
Location:34 → 349

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:13 → 353

G_alpha; G protein alpha subunit