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gphn.L gephyrin L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 779372, updated on 4-Nov-2024

Summary

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Official Symbol
gphn.L
Official Full Name
gephyrin L homeolog
Primary source
Xenbase:XB-GENE-989647
Locus tag
XELAEV_18040152mg
See related
EnsemblRapid:ENSXLAG00005031299 AllianceGenome:Xenbase:XB-GENE-989647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
gphn
Summary
Predicted to enable several functions, including ATP binding activity; molybdopterin adenylyltransferase activity; and molybdopterin molybdotransferase activity. Predicted to act upstream of or within several processes, including molybdenum incorporation into molybdenum-molybdopterin complex; postsynaptic neurotransmitter receptor diffusion trapping; and synapse organization. Predicted to be located in several cellular components, including dendrite; postsynaptic membrane; and postsynaptic specialization. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gphn.L in Genome Data Viewer
Location:
chromosome: 8L
Exon count:
29
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (112718089..112934423, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (97929269..98147636, complement)

Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit alpha L homeolog Neighboring gene ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D L homeolog Neighboring gene protein associated with LIN7 1, MAGUK p55 family member L homeolog Neighboring gene fucosyltransferase 8 (alpha (1,6) fucosyltransferase) L homeolog Neighboring gene MYC associated factor X L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC84626

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin molybdotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of synaptic specificity at neuromuscular junction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid receptor clustering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycine receptor clustering IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within molybdenum incorporation into molybdenum-molybdopterin complex IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within postsynaptic neurotransmitter receptor diffusion trapping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic specialization IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gephyrin L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096990.1 → NP_001090459.1  gephyrin L homeolog

    See identical proteins and their annotated locations for NP_001090459.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076865
    UniProtKB/TrEMBL
    Q6DF77
    Related
    ENSXLAP00005095003.1, ENSXLAT00005096723.1
    Conserved Domains (3) summary
    COG0303
    Location:442 → 851
    MoeA; Molybdopterin biosynthesis enzyme [Coenzyme transport and metabolism]
    cd00886
    Location:15 → 169
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:448 → 854
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    112718089..112934423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018229289.2 → XP_018084778.1  gephyrin L homeolog isoform X18

    UniProtKB/TrEMBL
    A0A8J0TJ11

  2. XM_018229287.2 → XP_018084776.1  gephyrin L homeolog isoform X17

    UniProtKB/TrEMBL
    A0A8J0THB2

  3. XM_018229286.2 → XP_018084775.1  gephyrin L homeolog isoform X15

    UniProtKB/TrEMBL
    A0A8J0T9G4

  4. XM_041572209.1 → XP_041428143.1  gephyrin L homeolog isoform X19

    UniProtKB/TrEMBL
    A0A8J1LF21
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:419 → 825
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  5. XM_041572208.1 → XP_041428142.1  gephyrin L homeolog isoform X16

    UniProtKB/TrEMBL
    A0A8J1LF32
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:430 → 836
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  6. XM_041572207.1 → XP_041428141.1  gephyrin L homeolog isoform X14

    UniProtKB/TrEMBL
    A0A8J1LFG0
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:451 → 857
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  7. XM_041572206.1 → XP_041428140.1  gephyrin L homeolog isoform X13

    UniProtKB/TrEMBL
    A0A8J1LHI8
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:460 → 866
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  8. XM_018229285.2 → XP_018084774.1  gephyrin L homeolog isoform X12

    UniProtKB/TrEMBL
    A0A8J0TFI5

  9. XM_018229282.2 → XP_018084771.1  gephyrin L homeolog isoform X10

    UniProtKB/TrEMBL
    A0A8J0TJ04

  10. XM_041572205.1 → XP_041428139.1  gephyrin L homeolog isoform X11

    UniProtKB/TrEMBL
    A0A8J1LGH7
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:494 → 900
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  11. XM_018229280.2 → XP_018084769.1  gephyrin L homeolog isoform X8

    UniProtKB/TrEMBL
    A0A8J0THA7
    Related
    ENSXLAP00005094542.1, ENSXLAT00005096245.1

  12. XM_018229281.2 → XP_018084770.1  gephyrin L homeolog isoform X9

    UniProtKB/TrEMBL
    A0A8J0TI37

  13. XM_018229276.2 → XP_018084765.1  gephyrin L homeolog isoform X6

    UniProtKB/TrEMBL
    A0A8J0TFI1
    Related
    ENSXLAP00005094281.1, ENSXLAT00005095983.1

  14. XM_041572200.1 → XP_041428134.1  gephyrin L homeolog isoform X2

    UniProtKB/TrEMBL
    A0A1L8FBD0, A0A974C938
    Related
    ENSXLAP00005093886.1, ENSXLAT00005095588.1
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:558 → 964
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  15. XM_041572202.1 → XP_041428136.1  gephyrin L homeolog isoform X4

    UniProtKB/TrEMBL
    A0A8J1LFF5
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:548 → 954
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  16. XM_041572204.1 → XP_041428138.1  gephyrin L homeolog isoform X7

    UniProtKB/TrEMBL
    A0A8J1LF16
    Related
    ENSXLAP00005094418.1, ENSXLAT00005096120.1
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:535 → 941
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  17. XM_041572201.1 → XP_041428135.1  gephyrin L homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J1LHI3
    Related
    ENSXLAP00005094009.1, ENSXLAT00005095711.1
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:556 → 962
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  18. XM_041572203.1 → XP_041428137.1  gephyrin L homeolog isoform X5

    UniProtKB/TrEMBL
    A0A8J1LF28
    Related
    ENSXLAP00005094144.1, ENSXLAT00005095846.1
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:546 → 952
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

  19. XM_041572199.1 → XP_041428133.1  gephyrin L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1LF11
    Conserved Domains (2) summary
    cd00886
    Location:50 → 204
    MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...
    cd00887
    Location:567 → 973
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
Nucleotide Protein Strain
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